Department of Medicine and Surgery, University of Milano-Bicocca, 20126 Milan, Italy.
J Biol Regul Homeost Agents. 2019 Nov-Dec;33(6 Suppl. 1):99-106.
The objective of this study was to compare the efficacy of supportive periodontal therapy (i.e. scaling and root planning, SRP) alone, versus a chemical device silica dioxide (SiO2) colloidal solutions (SDCS) used in association with SRP in the treatment of chronic periodontitis in adult patients. A total of 20 patients with a diagnosis of chronic periodontitis (40 localized chronic periodontitis sites) in the age group of 35 to 55 were selected. None of these patients have previously received any surgical or non-surgical periodontal therapy and demonstrated radiographic evidence of moderate bone loss. Two non-adjacent sites in separate quadrants were selected in each patient to monitor treatment efficacy (split mouth design). Clinical pocket depth (PD) and microbial analysis (MA) were analyzed at baseline day 15. SPSS program and paired simple statistic T-test were used to detect significant differences. Total bacteria loading, Tannerella forsitia and Treponema denticola loading were statistically reduced when SiO2 is locally delivered. SDCS gel is an adjuvant therapy which should be added to SRP in the management of moderate to severe chronic periodontitis.
本研究旨在比较单独使用支持性牙周治疗（即洁治和根面平整，SRP）与将二氧化硅（SiO2）胶体溶液（SDCS）化学器械联合使用治疗成人慢性牙周炎的疗效。共选择了 20 名年龄在 35 至 55 岁之间诊断为慢性牙周炎（40 个局部慢性牙周炎部位）的患者。这些患者均未接受过任何手术或非手术牙周治疗，且影像学显示有中度骨丧失。每位患者在不同象限选择两个非相邻部位来监测治疗效果（分口设计）。在基线第 15 天分析临床袋深度（PD）和微生物分析（MA）。使用 SPSS 程序和配对简单统计 T 检验来检测显著差异。当局部给予 SiO2 时，总细菌负荷、Tannerella forsitia 和 Treponema denticola 负荷均有统计学降低。SDCS 凝胶是一种辅助治疗方法，应在中重度慢性牙周炎的治疗中联合 SRP 使用。
