Inouye Brian D, Brosi Berry J, Le Sage Emily H, Lerdau Manuel T
Department of Biological Science, Florida State University, Tallahassee, FL 32306, USA.
Department of Biology, University of Washington, Seattle, WA 98105, USA.
Integr Comp Biol. 2022 Feb 5;61(6):2180-2189. doi: 10.1093/icb/icab178.
Biological systems are likely to be constrained by trade-offs among robustness, resilience, and performance. A better understanding of these trade-offs is important for basic biology, as well as applications where biological systems can be designed for different goals. We focus on redundancy and plasticity as mechanisms governing some types of trade-offs, but mention others as well. Whether trade-offs are due to resource constraints or "design" constraints (i.e., structure of nodes and links within a network) will also affect the types of trade-offs that are important. Identifying common themes across scales of biological organization will require that researchers use similar approaches to quantifying robustness, resilience, and performance, using units that can be compared across systems.
生物系统可能受到稳健性、恢复力和性能之间权衡的限制。更好地理解这些权衡对于基础生物学以及生物系统可针对不同目标进行设计的应用来说都很重要。我们将冗余和可塑性作为控制某些类型权衡的机制来重点关注，但也会提及其他机制。权衡是由于资源限制还是“设计”限制（即网络内节点和链接的结构）也会影响重要的权衡类型。识别生物组织不同尺度上的共同主题将要求研究人员使用类似的方法来量化稳健性、恢复力和性能，并使用可在不同系统间进行比较的单位。
