Calzavara-Pinton P, Cattaneo R, Franceschini F, Airò P
Divisione di Dermatologia, Spedali Civili di Brescia, Italy.
Boll Ist Sieroter Milan. 1987;66(3):239-42.
Kaposi's Sarcoma (KS) in young individuals is unusual and most often associated with cellular immunodeficiency caused by infective or other neoplastic diseases. It has recently been highly associated with the Acquired Immunodeficiency Syndrome (AIDS). We report the case of a heterosexual 29 year aged man with no evidence of underlying malignancy or infectious diseases. Antibodies to the Human Immunodeficiency Virus (HIV) were absent on repeat testing. His immunological profile demonstrated elevated number of CD8+ cells, normal number of CD3+ and CD4+ cells and hypogammaglobulinemia. These data are distinctly different from those described with AIDS associated KS. The development of KS in young individuals of mediterranean origin may reflect mild degree of immune abnormalities in the absence of infection with HIV.
卡波西肉瘤（KS）在年轻人中并不常见，且大多与由感染性疾病或其他肿瘤性疾病引起的细胞免疫缺陷有关。最近，它与获得性免疫缺陷综合征（艾滋病）高度相关。我们报告了一例29岁的异性恋男性病例，该患者没有潜在恶性肿瘤或传染病的证据。多次检测均未发现抗人类免疫缺陷病毒（HIV）抗体。他的免疫谱显示CD8 +细胞数量升高，CD3 +和CD4 +细胞数量正常，且存在低丙种球蛋白血症。这些数据与艾滋病相关的KS所描述的数据明显不同。地中海地区血统的年轻人中KS的发生可能反映了在未感染HIV的情况下存在轻度免疫异常。
