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气道软化症:临床特征及手术相关问题,一家三级儿科医院的十年经验

Airway Malacia: Clinical Features and Surgical Related Issues, a Ten-Year Experience from a Tertiary Pediatric Hospital.

作者信息

Ghezzi Michele, D'Auria Enza, Farolfi Andrea, Calcaterra Valeria, Zenga Alessandra, De Silvestri Annalisa, Pelizzo Gloria, Zuccotti Gian Vincenzo

机构信息

Allergology and Pneumology Unit, V. Buzzi Children's Hospital, 20154 Milan, Italy.

Department of Pediatrics, V. Buzzi Children's Hospital, 20154 Milan, Italy.

出版信息

Children (Basel). 2021 Jul 20;8(7):613. doi: 10.3390/children8070613.

Abstract

BACKGROUND

Few studies have been carried out with the aim of describing the clinical course and follow-up of patients with tracheomalacia. We aim to describe the symptoms at diagnosis and the post-treatment clinical course of patients affected by airway malacia.

METHODS

We retrospectively analyzed characteristics of pediatric patients with a diagnosis of airway malacia. Patients were classified into three groups: bronchomalacia (BM), tracheomalacia (TM) and tracheo-bronchomalacia (TBM). Demographic and clinical data, diagnostic work-up and surgical treatment were recorded.

RESULTS

13/42 patients were affected by congenital syndromes (30.9%). Esophageal atresia with or without tracheal-esophageal fistula (EA/TEF) was detected in 7/42 patients (16.7%). Cardiovascular anomalies were found in 9/42 (21.4%) and idiopathic forms in 13/42 (30.9%). BM occurred in 7/42 (16.6%), TM in 23/42 (54.7%) and TBM in 12/42 (28.6%). At the diagnosis stage, a chronic cough was reported in 50% of cases with a higher prevalence in EA/TEF ( = 0.005). Surgery was performed in 16/42 (40%) of children. A chronic cough and acute respiratory failure were correlated to the need for surgery. During follow-up, there was no difference in persistence of symptoms between conservative vs surgical treatment ( = 0.47).

CONCLUSION

the management of tracheomalacia remains a challenge for pediatricians. Clinical manifestations, such as a barking cough and acute respiratory failure may suggest the need for surgery. Follow-up is crucial, especially in those patients affected by comorbidities, so as to be able to manage effectively the possible persistence of symptoms, including those that may continue after surgical treatment.

摘要

背景

旨在描述气管软化症患者临床病程及随访情况的研究较少。我们旨在描述气道软化症患者诊断时的症状及治疗后的临床病程。

方法

我们回顾性分析了诊断为气道软化症的儿科患者的特征。患者分为三组:支气管软化症(BM)、气管软化症(TM)和气管支气管软化症(TBM)。记录人口统计学和临床数据、诊断检查及手术治疗情况。

结果

13/42例患者患有先天性综合征(30.9%)。42例患者中有7例(16.7%)检测出食管闭锁伴或不伴气管食管瘘(EA/TEF)。42例中有9例(21.4%)发现心血管异常,13例(30.9%)为特发性类型。BM发生于7/42例(16.6%),TM发生于23/42例(54.7%),TBM发生于12/42例(28.6%)。在诊断阶段,50%的病例报告有慢性咳嗽,在EA/TEF中患病率更高(P = 0.005)。16/42例(40%)儿童接受了手术。慢性咳嗽和急性呼吸衰竭与手术需求相关。在随访期间,保守治疗与手术治疗在症状持续方面无差异(P = 0.47)。

结论

气管软化症的管理对儿科医生来说仍然是一项挑战。临床表现,如犬吠样咳嗽和急性呼吸衰竭可能提示需要手术。随访至关重要,尤其是对那些患有合并症的患者,以便能够有效管理可能持续的症状,包括手术治疗后可能持续的症状。

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