Harlianto Netanja I, Westerink Jan, Foppen Wouter, Hol Marjolein E, Wittenberg Rianne, van der Veen Pieternella H, van Ginneken Bram, Kuperus Jonneke S, Verlaan Jorrit-Jan, de Jong Pim A, Mohamed Hoesein Firdaus A A
Department of Radiology, University Medical Center Utrecht and Utrecht University, 3584 CX Utrecht, The Netherlands.
Department of Orthopedic Surgery, University Medical Center Utrecht and Utrecht University, 3584 CX Utrecht, The Netherlands.
J Pers Med. 2021 Jul 15;11(7):663. doi: 10.3390/jpm11070663.
Diffuse idiopathic skeletal hyperostosis (DISH) is associated with both obesity and type 2 diabetes. Our objective was to investigate the relation between DISH and visceral adipose tissue (VAT) in particular, as this would support a causal role of insulin resistance and low grade inflammation in the development of DISH.
In 4334 patients with manifest vascular disease, the relation between different adiposity measures and the presence of DISH was compared using -scores via standard deviation logistic regression analyses. Analyses were stratified by sex and adjusted for age, systolic blood pressure, diabetes, non-HDL cholesterol, smoking status, and renal function.
DISH was present in 391 (9%) subjects. The presence of DISH was associated with markers of adiposity and had a strong relation with VAT in males (OR: 1.35; 95%CI: 1.20-1.54) and females (OR: 1.43; 95%CI: 1.06-1.93). In males with the most severe DISH (extensive ossification of seven or more vertebral bodies) the association between DISH and VAT was stronger (OR: 1.61; 95%CI: 1.31-1.98), while increased subcutaneous fat was negatively associated with DISH (OR: 0.65; 95%CI: 0.49-0.95). In females, increased subcutaneous fat was associated with the presence of DISH (OR: 1.43; 95%CI: 1.14-1.80).
Markers of adiposity, including VAT, are strongly associated with the presence of DISH. Subcutaneous adipose tissue thickness was negatively associated with more severe cases of DISH in males, while in females, increased subcutaneous adipose tissue was associated with the presence of DISH.
弥漫性特发性骨肥厚（DISH）与肥胖和2型糖尿病均相关。我们的目的是特别研究DISH与内脏脂肪组织（VAT）之间的关系，因为这将支持胰岛素抵抗和低度炎症在DISH发生发展中的因果作用。
在4334例有明显血管疾病的患者中，通过标准差逻辑回归分析使用z评分比较不同肥胖指标与DISH存在情况之间的关系。分析按性别分层，并对年龄、收缩压、糖尿病、非高密度脂蛋白胆固醇、吸烟状况和肾功能进行了校正。
391例（9%）受试者存在DISH。DISH的存在与肥胖指标相关，并且在男性（比值比：1.35；95%置信区间：1.20 - 1.54）和女性（比值比：1.43；95%置信区间：1.06 - 1.93）中与VAT有很强的关系。在患有最严重DISH（七个或更多椎体广泛骨化）的男性中，DISH与VAT之间的关联更强（比值比：1.61；95%置信区间：1.31 - 1.98），而皮下脂肪增加与DISH呈负相关（比值比：0.65；95%置信区间：0.49 - 0.95）。在女性中，皮下脂肪增加与DISH的存在相关（比值比：1.43；95%置信区间：1.14 - 1.80）。
包括VAT在内的肥胖指标与DISH的存在密切相关。皮下脂肪组织厚度在男性中与更严重的DISH病例呈负相关，而在女性中，皮下脂肪组织增加与DISH的存在相关。
