Department of Family Medicine, Healthcare Research Institute, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, Korea.
Department of Family Medicine, Seoul National University Hospital & College of Medicine, Seoul, Korea.
Sci Rep. 2017 Sep 8;7(1):10955. doi: 10.1038/s41598-017-09723-y.
The effect of visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) area on metabolic syndrome (MS) has been debated. We aimed to evaluate the effects of VAT and SAT on the incidence of MS and its components in a large and apparently healthy Asian population. We performed a longitudinal cohort study of 1,964 subjects who received health screenings over a 5-year follow-up period; 317 incidents of MS (16.1%) were observed during a median follow-up of 4.5 years. The VAT area was significantly associated with a higher incidence of MS; the adjusted HR for incident MS per 1 SD of VAT was 1.50 (95% CI 1.29-1.74), and the adjusted HR of the 5 VAT quintile compared with the 1 quintile was 3.73 (95% CI 2.22-6.28). However, the SAT area was not associated with incident MS. Although the VAT area was longitudinally associated with the incidence of each component of MS, the SAT area was inversely associated with the risk of high blood pressure, fasting blood sugar, and triglycerides, with marginal significance. In conclusion, the VAT area is longitudinally associated with an increased risk of incident MS, while SAT may have a protective effect against the incidence of individual MS components.
内脏脂肪组织 (VAT) 和皮下脂肪组织 (SAT) 面积对代谢综合征 (MS) 的影响一直存在争议。我们旨在评估 VAT 和 SAT 对大型且明显健康的亚洲人群中 MS 及其成分发病率的影响。我们对 1964 名接受了 5 年随访期健康筛查的受试者进行了一项纵向队列研究；在中位随访 4.5 年期间观察到 317 例 MS（16.1%）事件。VAT 面积与 MS 发病率显著相关；VAT 每增加 1SD，MS 事件的调整 HR 为 1.50（95%CI 1.29-1.74），与第 1 五分位数相比，第 5 五分位数的调整 HR 为 3.73（95%CI 2.22-6.28）。然而，SAT 面积与 MS 事件无关。尽管 VAT 面积与 MS 的每个组成部分的发病率呈纵向相关，但 SAT 面积与高血压、空腹血糖和甘油三酯的风险呈负相关，具有边缘意义。总之，VAT 面积与 MS 事件的发生风险呈正相关，而 SAT 可能对 MS 各个组成部分的发病率具有保护作用。
