Greenwood M F, Jones E A, Holland P
Am J Dis Child. 1978 Feb;132(2):131-5. doi: 10.1001/archpedi.1978.02120270029005.
The bactericidal activity of monocytes from a child with chronic benign granulocytopenia who has had virtual absence of neutrophils yet minimal infections since birth was examined against Escherichia coli and Staphylococcus aureus and compared with that of monocyte and neutrophils from 20 control subjects. Studies on monocyte function in this patient with no neutrophils revealed normal monocyte kill of both organisms when compared with control monocytes. Monocyte and neutrophil killing of both organisms was similar in control subjects at bacteria to phagocyte ratios of 1:1. When ratios of 3:1 were employed, however, control neutrophils were more effective than control and patient monocytes in reducing the number of viable organisms. These findings support the neutrophil as the more effective blood phagocyte but stress the importance of monocyte functional capacity in patients compromised by granulocytopenia or neutrophil functional defects.
对一名患有慢性良性粒细胞减少症的儿童的单核细胞的杀菌活性进行了检测，该儿童自出生以来几乎没有中性粒细胞，但感染极少。将其单核细胞对大肠杆菌和金黄色葡萄球菌的杀菌活性与20名对照受试者的单核细胞和中性粒细胞的杀菌活性进行了比较。对这名没有中性粒细胞的患者的单核细胞功能研究表明，与对照单核细胞相比，该患者的单核细胞对两种细菌的杀灭能力正常。在细菌与吞噬细胞比例为1:1时，对照受试者的单核细胞和中性粒细胞对两种细菌的杀灭能力相似。然而，当采用3:1的比例时，对照中性粒细胞在减少活菌数量方面比对照单核细胞和患者单核细胞更有效。这些发现支持中性粒细胞是更有效的血液吞噬细胞，但强调了单核细胞功能能力在因粒细胞减少症或中性粒细胞功能缺陷而受损的患者中的重要性。
