Kajander K C, Giesler G J
Department of Cell Biology and Neuroanatomy, University of Minnesota, Minneapolis 55455.
Brain Res. 1987 Dec 15;436(2):390-5. doi: 10.1016/0006-8993(87)91686-6.
Recent findings indicate that the lateral cervical nucleus (LCN) in cats is capable of transmitting to the ventrobasal thalamus information that may contribute to nociception. In the present study, we examined the effects of repeated noxious thermal stimulation on the responses of LCN neurons in unanesthetized cats that were decerebrated and partially spinalized. Seventeen LCN neurons were recorded that responded to noxious mechanical stimuli. The most responsive area of the receptive field of each neuron was exposed to repeated and sustained thermal stimuli of up to 55 degrees C. Such stimulation decreased the thermal thresholds of all 17 LCN neurons and increased the frequencies of their responses to identical thermal stimuli. The characteristics of this sensitization suggest that the spinocervicothalamic pathway receives a prominent input from A-nociceptors.
最近的研究结果表明，猫的外侧颈核（LCN）能够向腹侧基底丘脑传递可能有助于伤害感受的信息。在本研究中，我们检测了重复的伤害性热刺激对去大脑并部分脊髓横断的未麻醉猫的LCN神经元反应的影响。记录了17个对伤害性机械刺激有反应的LCN神经元。每个神经元感受野中反应最敏感的区域接受高达55摄氏度的重复持续热刺激。这种刺激降低了所有17个LCN神经元的热阈值，并增加了它们对相同热刺激的反应频率。这种敏化的特征表明脊髓颈丘脑通路从A类伤害感受器接收显著的输入。
