Dwyer J T, Goldin B, Gorbach S, Patterson J
Am J Hosp Pharm. 1978 Mar;35(3):278-87.
Dietary fiber and fiber supplements are reviewed, with particular emphasis on their sources, composition and properties; physiological actions on gastrointestinal functions; and uses in gastrointestinal disease states (functional bowel disease, diverticular disease and other conditions). Adverse effects and contraindications, and the hypothesis of diet's effect on colon cancer also are discussed. Dietary fiber supplements may relieve symptoms of constipation, spastic colon, and diverticular disease; in the two latter disorders, colonic pressure relationships are altered. It is concluded that current evidence does not support other therapeutic uses for dietary fiber sonstituents, except possibly in patients with anal fissures and hemorrhoids, which can be helped by the passage of a softer stool.
本文对膳食纤维及纤维补充剂进行了综述，特别强调了它们的来源、成分和特性；对胃肠功能的生理作用；以及在胃肠道疾病状态（功能性肠病、憩室病和其他病症）中的应用。还讨论了不良反应和禁忌症，以及饮食对结肠癌影响的假说。膳食纤维补充剂可能缓解便秘、结肠痉挛和憩室病的症状；在后两种疾病中，结肠压力关系会发生改变。得出的结论是，目前的证据不支持膳食纤维成分的其他治疗用途，可能除了肛裂和痔疮患者外，较软粪便的通过可能对其有帮助。
