Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, No.1 Jianshe East Road, Zhengzhou Henan Province, 450052, P. R. China.
College of Medicine, Henan Polytechnic University, Jiaozuo, 454000, P. R. China.
J Sep Sci. 2021 Oct;44(19):3562-3579. doi: 10.1002/jssc.202100310. Epub 2021 Aug 25.
Zilongjin tablets as a traditional Chinese medicine are widely used for primary lung cancer patients with deficiency of "qi " and "blood " syndrome undergoing chemotherapy. It is a compound preparation that consists of eight herbs. To clarify the chemical profiling of Zilong Jin tablets rapidly, a feasible and accurate strategy was developed by the ultra high performance liquid chromatography-quadrupole/orbitrap high resolution mass spectrometry. According to the accurate mass and fragment ion information provided by high resolution mass spectrometry, the compounds were reasonably identified. In total, 74 compounds were characterized, including 20 flavonoids, 14 quinones, 15 organic acids, 6 phthalide compounds, and 19 other compounds. Among them, 34 major compounds were unambiguously confirmed by comparing with reference standards. This study could provide an important scientific basis for further research on quality control, pharmacokinetics and pharmacodynamics, and clinical application of Zilong Jin tablets.
紫龙金片作为一种中药，广泛用于化疗的“气虚”和“血虚”型原发性肺癌患者。它是一种复方制剂，由八种草药组成。为了快速阐明紫龙金片的化学特征，采用超高效液相色谱-四极杆/轨道阱高分辨质谱法建立了一种可行且准确的策略。根据高分辨质谱提供的精确质量和碎片离子信息，对化合物进行了合理的鉴定。总共鉴定了 74 种化合物，包括 20 种黄酮类化合物、14 种醌类化合物、15 种有机酸、6 种邻苯二甲酸酯类化合物和 19 种其他化合物。其中，通过与对照品比较，明确鉴定了 34 种主要化合物。本研究可为进一步研究紫龙金片的质量控制、药代动力学和药效学以及临床应用提供重要的科学依据。
