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Epigenetic Regulation of Apoptosis in Cutaneous T-Cell Lymphoma: Implications for Therapy with Methotrexate, Jak Inhibitors, and Resveratrol.

作者信息

Nihal Minakshi, Wu Jianqiang, Stonesifer Connor J, Daniels Jay, Choi Jaehyuk, Geskin Larisa, Rook Alain H, Wood Gary S

机构信息

Department of Dermatology, The School of Medicine and Public Health, University of Wisconsin and William S. Middleton VAMC, Madison, Wisconsin, USA.

Department of Dermatology, The School of Medicine and Public Health, University of Wisconsin and William S. Middleton VAMC, Madison, Wisconsin, USA.

出版信息

J Invest Dermatol. 2022 Feb;142(2):493-496.e7. doi: 10.1016/j.jid.2021.06.034. Epub 2021 Aug 3.

DOI:10.1016/j.jid.2021.06.034
PMID:34358529
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9017049/
Abstract
摘要

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本文引用的文献

1
The 2018 update of the WHO-EORTC classification for primary cutaneous lymphomas.2018 年版 WHO-EORTC 原发性皮肤淋巴瘤分类。
Blood. 2019 Apr 18;133(16):1703-1714. doi: 10.1182/blood-2018-11-881268. Epub 2019 Jan 11.
2
Epigenetic Regulatory Mechanisms Induced by Resveratrol.白藜芦醇诱导的表观遗传调控机制。
Nutrients. 2017 Nov 1;9(11):1201. doi: 10.3390/nu9111201.
3
Interleukin 6 induces cell proliferation of clear cell renal cell carcinoma by suppressing hepaCAM via the STAT3-dependent up-regulation of DNMT1 or DNMT3b.白细胞介素6通过依赖STAT3上调DNMT1或DNMT3b抑制肝细胞膜相关蛋白，从而诱导肾透明细胞癌的细胞增殖。
Cell Signal. 2017 Apr;32:48-58. doi: 10.1016/j.cellsig.2017.01.017. Epub 2017 Jan 16.
4
Mutated JAK kinases and deregulated STAT activity are potential therapeutic targets in cutaneous T-cell lymphoma.突变的JAK激酶和失调的STAT活性是皮肤T细胞淋巴瘤潜在的治疗靶点。
Haematologica. 2015 Nov;100(11):e450-3. doi: 10.3324/haematol.2015.132837. Epub 2015 Aug 20.
5
Genomic landscape of cutaneous T cell lymphoma.皮肤T细胞淋巴瘤的基因组格局
Nat Genet. 2015 Sep;47(9):1011-9. doi: 10.1038/ng.3356. Epub 2015 Jul 20.
6
Methotrexate Is a JAK/STAT Pathway Inhibitor.甲氨蝶呤是一种JAK/STAT信号通路抑制剂。
PLoS One. 2015 Jul 1;10(7):e0130078. doi: 10.1371/journal.pone.0130078. eCollection 2015.
7
Critical role for lysine 685 in gene expression mediated by transcription factor unphosphorylated STAT3.赖氨酸 685 在转录因子未磷酸化 STAT3 介导的基因表达中起关键作用。
J Biol Chem. 2014 Oct 31;289(44):30763-30771. doi: 10.1074/jbc.M114.603894. Epub 2014 Sep 12.
8
The Janus kinase 2 inhibitor fedratinib inhibits thiamine uptake: a putative mechanism for the onset of Wernicke's encephalopathy.酪氨酸激酶2抑制剂fedratinib抑制硫胺素摄取：韦尼克脑病发病的一种可能机制。
Drug Metab Dispos. 2014 Oct;42(10):1656-62. doi: 10.1124/dmd.114.058883. Epub 2014 Jul 25.
9
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