Mako M E, Starr J I, Rubenstein A H
Am J Med. 1977 Dec;63(6):865-9. doi: 10.1016/0002-9343(77)90538-1.
The contribution of proinsulin to the total serum immunoreactive insulin (IRI) was measured in 59 patients with maturity onset diabetes (23 being treated with diet alone and 36 with oral sulfonylurea agents) and compared to that in 44 control subjects. The percentage of proinsulin was increased in 11 patients and correlated with plasma glucose, but not with IRI. There was no difference between the drug-treated group and diet-treated group, or between patients taking different sulfonylurea agents. Sequential studies in one patient showed normalization of the proportion of proinsulin following lowering of the plasma glucose level. It is probably that the increased circulating proportion of proinsulin in hyperglycemic diabetic patients is secondary to beta cell exhaustion with release of less mature granules.
对59例成年型糖尿病患者（其中23例仅接受饮食治疗，36例接受口服磺脲类药物治疗）测定了胰岛素原对血清总免疫反应性胰岛素（IRI）的贡献，并与44例对照受试者进行了比较。11例患者的胰岛素原百分比升高，且与血糖相关，但与IRI无关。药物治疗组和饮食治疗组之间，以及服用不同磺脲类药物的患者之间均无差异。对1例患者的连续研究显示，血糖水平降低后胰岛素原比例恢复正常。高血糖糖尿病患者循环中胰岛素原比例增加，可能是β细胞耗竭并释放较不成熟颗粒的结果。
