Insights into the molecular mechanism of tetracycline transport in saturated porous media affected by low-molecular-weight organic acids: Role of the functional groups and molecular size.

The transport of tetracycline possessed a great challenge in its environmental applications. This study looked at how various low-molecular-weight organic acids (LMWOAs) affect the transport of tetracycline in environments. To that end, four LMWOAs were employed in experiments; acetic acid, malonic acid, malic acid, and citric acid. It was observed that LMWOAs promoted the tetracycline passage in presence of various experimental environments. The LMWOAs steric hindrance and deposition competition facilitated tetracycline transport at pH 5.0. The other deposition mechanism for tetracycline was the electrostatic repulsion between tetracycline and sand enhanced by deprotonated LMWOAs at pH 7.0. Moreover, the enhanced effects of LMWOAs on tetracycline mobility were intensively dependent on LMWOA type with more functional groups (e.g. carboxyl and hydroxyl groups) and larger molecular size supported stronger deposition competition, steric hindrance as well as electrostatic repulsion. Additionally, cation-bridging played a vital role for the enhanced effects of LMWOAs on tetracycline transport with divalent cations (e.g., Ca and Pb). Interestingly, tetracycline exhibited a higher mobility in the presence of Ca relative to Pb regardless of LMWOAs-free or LMWOAs-addition. This phenomenon was attributed to the fact that Pb has a greater affinity with tetracycline and LMWOAs than Ca. Furthermore, under the shadow of numerous LMWOAs, the non-equilibrium two site transportation model was employed to investigate the movement of tetracycline in porous saturated media. The present study suggests that LMWOAs may be important considerations in assessing the antibiotic passage in soil as well as groundwater.