Motono Nozomu, Ishikawa Masahito, Iwai Shun, Iijima Yoshihito, Uramoto Hidetaka
Department of Thoracic Surgery, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Ishikawa 920-0293, Japan.
Int J Surg Case Rep. 2021 Aug;85:106254. doi: 10.1016/j.ijscr.2021.106254. Epub 2021 Jul 31.
Renal infarction after pulmonary resection is relatively rare; however, it is associated with severe morbidity.
An 80-year-old woman without any severe comorbidity or smoking history underwent left upper lobectomy (LUL) concomitant with mediastinal lymph node dissection for lung adenocarcinoma. She did not show fever, flank pain, and/or nausea; however, laboratory data revealed an elevated white blood cell count (WBC) (13,460 cells/mm) and elevated serum lactate dehydrogenase (LDH) (670 IU/L) and C-reactive protein (CRP) (23.6 mg/dL) levels on the fifth postoperative day. Contrast-enhanced computed tomography from the thorax to the pelvic cavity revealed a partial defect of the right kidney without any indication of infection and no pulmonary vein stump thrombosis. We diagnosed the patient with partial right renal infarction, and heparin (10,000 IU/day) was initiated. Laboratory data showed gradual reduction in the WBC (7700 cells/mm), as well as in the serum LDH (355 IU/L) and CRP (0.76 mg/dL) levels, 7 days after heparin initiation. Anticoagulation therapy including heparin administration was discontinued because renal function remained, and we observed no pulmonary vein stump thrombosis. Laboratory data remained within normal limits, and the patient was discharged on postoperative day 15.
LUL is considered a risk factor for this condition, and elevated WBC, as well as serum LDH and CRP levels are useful diagnostic indicators.
肺切除术后肾梗死相对少见;然而,它与严重的发病率相关。
一名80岁女性,无任何严重合并症或吸烟史,因肺腺癌接受了左上肺叶切除术(LUL)并同时进行纵隔淋巴结清扫。她未出现发热、侧腹痛和/或恶心;然而,实验室数据显示术后第5天白细胞计数(WBC)升高(13,460个细胞/mm)、血清乳酸脱氢酶(LDH)升高(670 IU/L)和C反应蛋白(CRP)升高(23.6 mg/dL)。从胸部到盆腔的增强计算机断层扫描显示右肾部分缺损,无任何感染迹象且无肺静脉残端血栓形成。我们诊断该患者为右肾部分梗死,并开始使用肝素(10,000 IU/天)。开始使用肝素7天后,实验室数据显示白细胞(7700个细胞/mm)、血清LDH(355 IU/L)和CRP(0.76 mg/dL)水平逐渐降低。由于肾功能保持正常且未观察到肺静脉残端血栓形成,包括肝素给药在内的抗凝治疗停止。实验室数据保持在正常范围内,患者于术后第15天出院。
左上肺叶切除术被认为是这种情况的一个危险因素,白细胞升高以及血清LDH和CRP水平是有用的诊断指标。