双相障碍患者在进行眼神辨别时，心理化大脑系统的异常激活。
Aberrant activation of the mentalizing brain system during eye gaze discrimination in bipolar disorder.
机构信息
Department of Psychiatry, University of Michigan, Ann Arbor, United States.
Department of Psychiatry, University of Michigan, Ann Arbor, United States.
出版信息
Psychiatry Res Neuroimaging. 2021 Sep 30;315:111340. doi: 10.1016/j.pscychresns.2021.111340. Epub 2021 Jul 31.
Abstract
Bipolar disorder (BD) is associated with a range of social cognitive deficits. This study investigated the functioning of the mentalizing brain system in BD probed by an eye gaze perception task during fMRI. Compared with healthy controls (n = 21), BD participants (n = 14) showed reduced preferential activation for self-directed gaze discrimination in the medial prefrontal cortex (mPFC) and temporo-parietal junction (TPJ), which was associated with poorer cognition/social cognition. Aberrant functions of the mentalizing system should be further investigated as marker of social dysfunction and treatment targets.
摘要
双相情感障碍（BD）与一系列社会认知缺陷有关。本研究通过 fMRI 中的眼动感知任务研究了精神状态识别大脑系统在 BD 中的功能。与健康对照组（n=21）相比，BD 患者（n=14）在前内侧前额叶皮层（mPFC）和颞顶联合区（TPJ）中对自我导向注视辨别显示出降低的优先激活，这与较差的认知/社会认知相关。精神状态识别系统的异常功能应作为社会功能障碍和治疗靶点的标志物进一步研究。
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