传染性胰腺坏死病毒及共感染对虹鳟鱼非特异性免疫系统的影响（）。

Influence of Infectious Pancreatic Necrosis Virus and Co-Infection on a Non-Specific Immune System in Rainbow Trout ().

作者信息

Pajdak-Czaus Joanna, Schulz Patrycja, Terech-Majewska Elżbieta, Szweda Wojciech, Siwicki Andrzej Krzysztof, Platt-Samoraj Aleksandra

机构信息

Department of Epizootiology, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowskiego 13, 10-718 Olsztyn, Poland.

Department of Ichthyopathology and Fish Health Prevention, S. Sakowicz Inland Fisheries Institute, Główna 48, 05-500 Żabieniec, Poland.

出版信息

Animals (Basel). 2021 Jul 2;11(7):1974. doi: 10.3390/ani11071974.

DOI:10.3390/ani11071974

PMID:34359116

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8300417/

Abstract

BACKGROUND

The IPNV is one of the most common viral pathogens of rainbow trout (), while infections are widespread among bacterial agents. The current study aimed to determine the influence of IPNV and co-infection on a non-specific immune response.

METHODS

Two experiments were conducted. The first experiment determined the changes in non-specific immunity parameters upon the simultaneous occurrence of IPNV and infection. In the second experiment, infection with the IPNV was performed two weeks before infection. The level of total protein, gamma globulins, the activity of lysozyme and ceruloplasmin, as well as the metabolic activity and potential killing activity of phagocytes were measured: 0, 24 h, 72 h, 7 days, 14 days, and 21 days after co-infection.

RESULTS

A differentiated effect on the parameters of the non-specific immune response was shown between single infections with the IPNV and as well as co-infection with these pathogens.

CONCLUSIONS

The immune response in the course of a co-infection depended on the time between infections. IPNV infection causes lysozyme activity suppression, which may lead to secondary bacterial infections.

摘要

背景

传染性胰腺坏死病毒（IPNV）是虹鳟最常见的病毒病原体之一，而细菌感染也很普遍。本研究旨在确定IPNV与[细菌名称未给出]共同感染对非特异性免疫反应的影响。

方法

进行了两项实验。第一个实验确定了IPNV与[细菌名称未给出]同时感染时非特异性免疫参数的变化。在第二个实验中，在[细菌名称未给出]感染前两周进行IPNV感染。在共同感染后的0、24小时、72小时、7天、14天和21天测量总蛋白、γ球蛋白水平、溶菌酶和铜蓝蛋白活性，以及吞噬细胞的代谢活性和潜在杀伤活性。