Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-901, RJ, Brazil.
Instituto Nacional de Ciência e Tecnologia em Biologia Estrutural e Bioimagem, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-590, RJ, Brazil.
Int J Mol Sci. 2021 Jul 21;22(15):7768. doi: 10.3390/ijms22157768.
Inorganic phosphate (Pi) is an essential nutrient for living organisms and is maintained in equilibrium in the range of 0.8-1.4 mM Pi. Pi is a source of organic constituents for DNA, RNA, and phospholipids and is essential for ATP formation mainly through energy metabolism or cellular signalling modulators. In mitochondria isolated from the brain, liver, and heart, Pi has been shown to induce mitochondrial reactive oxygen species (ROS) release. Therefore, the purpose of this review article was to gather relevant experimental records of the production of Pi-induced reactive species, mainly ROS, to examine their essential roles in physiological processes, such as the development of bone and cartilage and the development of diseases, such as cardiovascular disease, diabetes, muscle atrophy, and male reproductive system impairment. Interestingly, in the presence of different antioxidants or inhibitors of cytoplasmic and mitochondrial Pi transporters, Pi-induced ROS production can be reversed and may be a possible pharmacological target.
无机磷酸盐（Pi）是生物体必需的营养物质，其在 0.8-1.4mM Pi 的范围内保持平衡。Pi 是 DNA、RNA 和磷脂的有机成分的来源，对通过能量代谢或细胞信号转导调节剂形成 ATP 至关重要。已经表明，在从大脑、肝脏和心脏分离的线粒体中，Pi 会诱导线粒体活性氧（ROS）的释放。因此，本文综述的目的是收集 Pi 诱导的活性物质（主要是 ROS）产生的相关实验记录，以检查其在生理过程中的重要作用，如骨骼和软骨的发育以及心血管疾病、糖尿病、肌肉萎缩和男性生殖系统损伤等疾病的发展。有趣的是，在存在不同的抗氧化剂或细胞质和线粒体 Pi 转运体抑制剂的情况下，Pi 诱导的 ROS 产生可以被逆转，这可能是一个潜在的药理学靶点。
