先天性畸形的发病机制。一种假说。
Pathogenesis of congenital malformations. An hypothesis.
作者信息
McCredie J, Loewenthal J
出版信息
Am J Surg. 1978 Mar;135(3):293-7. doi: 10.1016/0002-9610(78)90055-7.
PMID:343618
Abstract
An hypothesis of neural crest injury, derived from a radiologic analysis of thalidomide deformities, is suggested as a possible pathogenetic mechanism of dysmelia and its associated visceral defects. Supportive evidence from a variety of sources is presented, and the hypothesis is shown to provide a unifying concept for a number of previously unrelated facts.
摘要
基于对沙利度胺所致畸形的放射学分析得出的神经嵴损伤假说，被认为是肢体发育异常及其相关内脏缺陷可能的发病机制。文中呈现了来自各种来源的支持性证据，且该假说被证明可为一些此前互不相关的事实提供一个统一的概念。
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