沙利度胺致畸作用的机制。

Mechanism of the teratogenic effect of thalidomide.

作者信息

McCredie J

出版信息

Med Hypotheses. 1976 Mar-Apr;2(2):63-9. doi: 10.1016/0306-9877(76)90064-5.

Abstract

The mechanism of the teratogenic effect of thalidomide is unknown. The hypothesis that this drug acts on the sensory nerves of the embryo was derived from radiological observations of two series of thalidomide-deformed children. Supplementary evidence was found in neurological, embryological and other literature, to support the hypothesis of embryonic neuropathy. The concept can be extended to include visceral as well as skeletal deformities. Evidence for and against the hypothesis is presented, and its application to a broad spectrum of congenital deformities provides an explanation of a number of previously unrelated facts. Areas for further research are suggested.

摘要

沙利度胺致畸作用的机制尚不清楚。关于这种药物作用于胚胎感觉神经的假说源自对两组沙利度胺致畸形儿童的放射学观察。在神经学、胚胎学及其他文献中发现了补充证据，以支持胚胎神经病变的假说。这一概念可以扩展到包括内脏以及骨骼畸形。文中给出了支持和反对该假说的证据，并且其在广泛先天性畸形中的应用为许多以前不相关的事实提供了解释。还提出了进一步研究的领域。