褪黑素在血管紧张素和衰老中的作用。

Role of Melatonin in Angiotensin and Aging.

作者信息

Sehirli Ahmet Ozer, Sayıner Serkan, Chukwunyere Ugochukwu, Serakinci Nedime

机构信息

Department of Pharmacology, Faculty of Dentistry, Near East University, North Cyprus, Mersin 10, Nicosia 99138, Turkey.

Department of Biochemistry, Faculty of Veterinary Medicine, Near East University, North Cyprus, Mersin 10, Nicosia 99138, Turkey.

出版信息

Molecules. 2021 Jul 31;26(15):4666. doi: 10.3390/molecules26154666.

DOI:10.3390/molecules26154666

PMID:34361818

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8347812/

Abstract

The cellular utilization of oxygen leads to the generation of free radicals in organisms. The accumulation of these free radicals contributes significantly to aging and several age-related diseases. Angiotensin II can contribute to DNA damage through oxidative stress by activating the NAD(P)H oxidase pathway, which in turn results in the production of reactive oxygen species. This radical oxygen-containing molecule has been linked to aging and several age-related disorders, including renal damage. Considering the role of angiotensin in aging, melatonin might relieve angiotensin-II-induced stress by enhancing the mitochondrial calcium uptake 1 pathway, which is crucial in preventing the mitochondrial calcium overload that may trigger increased production of reactive oxygen species and oxidative stress. This review highlights the role and importance of melatonin together with angiotensin in aging and age-related diseases.

摘要

细胞对氧气的利用会导致生物体内产生自由基。这些自由基的积累对衰老和几种与年龄相关的疾病有显著影响。血管紧张素II可通过激活NAD(P)H氧化酶途径，经由氧化应激导致DNA损伤，进而产生活性氧。这种含自由基的分子与衰老和几种与年龄相关的疾病有关，包括肾损伤。考虑到血管紧张素在衰老中的作用，褪黑素可能通过增强线粒体钙摄取1途径来缓解血管紧张素II诱导的应激，这对于防止可能引发活性氧产生增加和氧化应激的线粒体钙超载至关重要。本综述强调了褪黑素和血管紧张素在衰老及与年龄相关疾病中的作用和重要性。