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褪黑素对老年 COVID-19 患者线粒体氧化还原活性受损的潜在影响综述

A Review of the Potential Effects of Melatonin in Compromised Mitochondrial Redox Activities in Elderly Patients With COVID-19.

作者信息

Su Wen-Lin, Wu Chia-Chao, Wu Shu-Fang Vivienne, Lee Mei-Chen, Liao Min-Tser, Lu Kuo-Cheng, Lu Chien-Lin

机构信息

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan.

School of Medicine, Tzu Chi University, Hualien, Taiwan.

出版信息

Front Nutr. 2022 Jun 20;9:865321. doi: 10.3389/fnut.2022.865321. eCollection 2022.

DOI:10.3389/fnut.2022.865321
PMID:35795579
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9251345/
Abstract

Melatonin, an endogenous indoleamine, is an antioxidant and anti-inflammatory molecule widely distributed in the body. It efficiently regulates pro-inflammatory and anti-inflammatory cytokines under various pathophysiological conditions. The melatonin rhythm, which is strongly associated with oxidative lesions and mitochondrial dysfunction, is also observed during the biological process of aging. Melatonin levels decline considerably with age and are related to numerous age-related illnesses. The signs of aging, including immune aging, increased basal inflammation, mitochondrial dysfunction, significant telomeric abrasion, and disrupted autophagy, contribute to the increased severity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. These characteristics can worsen the pathophysiological response of the elderly to SARS-CoV-2 and pose an additional risk of accelerating biological aging even after recovery. This review explains that the death rate of coronavirus disease (COVID-19) increases with chronic diseases and age, and the decline in melatonin levels, which is closely related to the mitochondrial dysfunction in the patient, affects the virus-related death rate. Further, melatonin can enhance mitochondrial function and limit virus-related diseases. Hence, melatonin supplementation in older people may be beneficial for the treatment of COVID-19.

摘要

褪黑素是一种内源性吲哚胺，是一种广泛分布于体内的抗氧化和抗炎分子。它在各种病理生理条件下有效地调节促炎和抗炎细胞因子。在衰老的生物学过程中也观察到褪黑素节律，它与氧化损伤和线粒体功能障碍密切相关。褪黑素水平会随着年龄的增长而大幅下降，并且与许多与年龄相关的疾病有关。衰老的迹象，包括免疫衰老、基础炎症增加、线粒体功能障碍、端粒显著磨损和自噬紊乱，会导致严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染的严重程度增加。这些特征会使老年人对SARS-CoV-2的病理生理反应恶化，甚至在康复后也会带来加速生物衰老的额外风险。这篇综述解释了冠状病毒病（COVID-19）的死亡率会随着慢性病和年龄的增长而增加，而与患者线粒体功能障碍密切相关的褪黑素水平下降会影响病毒相关的死亡率。此外，褪黑素可以增强线粒体功能并限制病毒相关疾病。因此，在老年人中补充褪黑素可能对治疗COVID-19有益。

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