Su Jie-Min, Zheng Qing-Zhong, Huang Wen-Rong, Deng Jing, Wu Jun, Lu Hong-Quan
Department of Radiology,Hainan West Central Hospital, Danzhou 571799, Hainan Province, China.
Department of Radiology,Hainan West Central Hospital, Danzhou 571799, Hainan Province, China E-mail:
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2021 Aug;29(4):1181-1186. doi: 10.19746/j.cnki.issn.1009-2137.2021.04.025.
To investigate the prognostic value of metabolic parameters of F-fluorodeoxyglucose (F-FDG) positron emission tomography/computed tomography (PET/CT) in diffuse large B-cell lymphoma (DLBCL).
The clinical data of 58 patients with DLBCL who were examined by F-FDG PET/CT before treatment and confirmed by pathology were analyzed retrospectively. The relationships between maximum standardized uptake value (SUV), metabolic tumor volume (MTV), total lesion glycolysis (TLG) and clinical factors were analyzed. Kaplan Meier method, Log-rank test and multivariate Cox regression were used to analyze the relationships between metabolic SUV, MTV, TLG and times of total overall survival (OS) and progression-free survival (PFS).
The SUV, MTV and TLG of 58 DLBCL patients were 21.45 (10.26-42.38), 27.30 (14.20-133.25) cm and 322.85 (47.35-1438.20), respectively. Univariate analysis showed that large mass, Ann Arbor stage, international prognostic index, MTV and TLG were the factors influencing OS and PFS in DLBCL patients (P<0.05), while lactate dehydrogenase and SUV were the factors influencing PFS only (P<0.05). Multivariate analysis showed that MTV (HR=2.974, 95%CI: 1.803-7.225)/(HR=3.925, 95%CI: 1.973-8.246) and TLG (HR=2.583, 95%CI: 1.192-5.316)/(HR=2.874, 95%CI: 1.538-6.483) were independent risk factors for OS and PFS in DLBCL patients (P<0.05), and international prognostic index (HR=2.490, 95%CI: 1.150-4.962) was independent risk factor for OS in DLBCL patients (P<0.05).
MTV and TLG are independent risk factors for OS and PFS in patients with DLBCL, which may be valuable for prognosis of patients with DLBCL.
探讨¹⁸F-氟脱氧葡萄糖（¹⁸F-FDG）正电子发射断层显像/计算机断层扫描（PET/CT）代谢参数在弥漫性大B细胞淋巴瘤（DLBCL）中的预后价值。
回顾性分析58例治疗前接受¹⁸F-FDG PET/CT检查并经病理确诊的DLBCL患者的临床资料。分析最大标准化摄取值（SUV）、代谢肿瘤体积（MTV）、总病灶糖酵解（TLG）与临床因素之间的关系。采用Kaplan-Meier法、Log-rank检验和多因素Cox回归分析代谢SUV、MTV、TLG与总生存（OS）时间和无进展生存（PFS）时间之间的关系。
58例DLBCL患者的SUV、MTV和TLG分别为21.45（10.26 - 42.38）、27.30（14.20 - 133.25）cm³和322.85（47.35 - 1438.20）。单因素分析显示，大包块、Ann Arbor分期、国际预后指数、MTV和TLG是影响DLBCL患者OS和PFS的因素（P<0.05），而乳酸脱氢酶和SUV仅是影响PFS的因素（P<0.05）。多因素分析显示，MTV（HR = 2.974，95%CI：1.803 - 7.2
