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The unknown human trophectoderm: implication for biopsy at the blastocyst stage.未知的人类滋养外胚层：对囊胚阶段活检的影响。
J Assist Reprod Genet. 2020 Nov;37(11):2699-2711. doi: 10.1007/s10815-020-01925-0. Epub 2020 Sep 6.
3
Trophectoderm biopsy reduces the level of serum β-human chorionic gonadotropin in early pregnancy.滋养层细胞活检会降低早孕期间血清β-人绒毛膜促性腺激素水平。
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Mol Med Rep. 2020 Apr;21(4):1897-1909. doi: 10.3892/mmr.2020.10971. Epub 2020 Jan 31.
5
Maternal and neonatal outcomes associated with trophectoderm biopsy.滋养层活检相关的母婴结局。
Fertil Steril. 2019 Aug;112(2):283-290.e2. doi: 10.1016/j.fertnstert.2019.03.033. Epub 2019 May 15.
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Neonatal outcomes of live births after blastocyst biopsy in preimplantation genetic testing cycles: a follow-up of 1,721 children.囊胚活检后的活产新生儿结局：一项对 1721 名儿童的随访研究。
Fertil Steril. 2019 Jul;112(1):82-88. doi: 10.1016/j.fertnstert.2019.03.006. Epub 2019 May 2.
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Does blastomere removal alter the expression level of miR-Let7a and its target genes following mouse embryo biopsy?卵裂球去除是否会改变小鼠胚胎活检后 miR-Let7a 及其靶基因的表达水平？
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Large for gestational age and macrosomia in singletons born after frozen/thawed embryo transfer (FET) in assisted reproductive technology (ART).冻融胚胎移植（FET）后辅助生殖技术（ART）中单胎出生的巨大儿和大于胎龄儿。
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假说：人滋养层细胞活检下调胎盘生长因子基因的表达。

Hypothesis: human trophectoderm biopsy downregulates the expression of the placental growth factor gene.

机构信息

Gruppo Donnamed, Reproductive Medicine Unit, Via Cassia 1110, Rome, Italy.

出版信息

J Assist Reprod Genet. 2021 Oct;38(10):2575-2578. doi: 10.1007/s10815-021-02283-1. Epub 2021 Aug 7.

DOI:10.1007/s10815-021-02283-1
PMID:34363571
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8581080/
Abstract

Preeclampsia (PE) and intrauterine growth retardation (IUGR) are the results of defective placentation associated with the downregulation of different genes in the human trophoblast including the Placental Growth Factor (PGF). TrophEctoderm (TE) biopsy is increasingly performed for Pre-implantation Genetic Testing of Aneuploidies and it involves the traumatical removal of an unpredictable number of mural TE cells from the human blastocyst. We observed strikingly similar obstetrical and neonatal complications in pregnancies where the placenta bears PGF downmodulation or a TE biopsy has been done. In both groups, the risk of PE, IUGR, congenital cardiac ventricular septal defects, caesarean section, sex ratio in favour of males and preterm birth is significantly increased compared to controls. Given the high degree of correlation, the observation may not be a casual one. We postulate herein that the TE biopsy may induce persistent dysregulation of different genes in the placenta including PGF. The mechanism proposed is the disruption of tight junctions caused by the TE biopsy.

摘要

子痫前期 (PE) 和宫内生长受限 (IUGR) 是与人类滋养层中不同基因下调相关的胎盘功能不全的结果，包括胎盘生长因子 (PGF)。滋养外胚层 (TE) 活检越来越多地用于非整倍体的胚胎植入前基因检测，它涉及从人类囊胚中创伤性地去除不可预测数量的壁 TE 细胞。我们观察到在胎盘存在 PGF 下调或进行 TE 活检的妊娠中，产科和新生儿并发症惊人地相似。在这两组中，与对照组相比，PE、IUGR、先天性心脏室间隔缺损、剖宫产、男性比例和早产的风险显著增加。鉴于高度相关性，观察结果可能不是偶然的。我们在此假设 TE 活检可能会导致胎盘内不同基因包括 PGF 的持续失调。提出的机制是 TE 活检引起的紧密连接破坏。