Osuna-Soto Julio, Caro Cuenca Teresa, Sanz-Zorrilla Alicia, Torrecilla-Martínez Antonio, Ortega Salas Rosa, Leiva-Cepas Fernando
Departamento de Ciencias Morfológicas y Sociosanitarias, Facultad de Medicina y Enfermería, Universidad de Córdoba, Córdoba, España.
Servicio de Anatomía Patológica, Hospital Universitario Reina Sofía de Córdoba, Córdoba, España.
Cir Esp (Engl Ed). 2021 Aug 5. doi: 10.1016/j.ciresp.2021.06.010.
The main objective is to establish the overall survival and disease-free survival profiles regarding the patients with retroperitoneal liposarcoma, making a comparison based on the well-differentiated and dedifferentiated histological subtypes. The secondary objectives are to descriptively analyze the clinical characteristics of said patients and to identify and analyze other independent variables that might modify these survival profiles significantly.
An observational and analytical study was performed using a retrospective historical cohort that was followed prospectively. The inclusion criteria consisted of: the procedure of liposarcoma located in the retroperitoneum, the well-differentiated and dedifferentiated histological subtypes, between January 2002 and May 2019. As a result, 32 patients took part in this study's sample. Kaplan-Meier estimator was used to summarize the results and log-rank test was used in the comparative analysis.
The overall survival at 5 years was around 59%. No differences were found between the patients with a well-differentiated subtype compared to the dedifferentiated ones (p=0.834). The disease-free survival at 2 years was 59% regarding the well-differentiated and 26% regarding the dedifferentiated, with these differences being statistically significant (p=0.005). None of the other studied variables modified these survival profiles significantly.
Dedifferentiated retroperitoneal liposarcomas show less disease-free survival than well-differentiated liposarcomas. However, regarding overall survival no differences can be claimed.
主要目的是确定腹膜后脂肪肉瘤患者的总生存期和无病生存期情况，并基于高分化和去分化组织学亚型进行比较。次要目的是描述性分析上述患者的临床特征，并识别和分析可能显著改变这些生存情况的其他独立变量。
采用回顾性历史队列进行前瞻性观察分析研究。纳入标准包括：2002年1月至2019年5月期间位于腹膜后的脂肪肉瘤手术、高分化和去分化组织学亚型。结果，32例患者参与了本研究样本。采用Kaplan-Meier估计量总结结果，采用对数秩检验进行比较分析。
5年总生存率约为59%。高分化亚型患者与去分化亚型患者之间未发现差异（p=0.834）。高分化患者2年无病生存率为59%，去分化患者为26%，这些差异具有统计学意义（p=0.005）。其他研究变量均未显著改变这些生存情况。
去分化腹膜后脂肪肉瘤的无病生存期低于高分化脂肪肉瘤。然而，在总生存期方面，未发现差异。
