理解并利用上皮-间充质相互作用在掌跖身份发育中的作用。
Understanding and Harnessing Epithelial‒Mesenchymal Interactions in the Development of Palmoplantar Identity.
机构信息
Department of Dermatology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Department of Dermatology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
出版信息
J Invest Dermatol. 2022 Feb;142(2):282-284. doi: 10.1016/j.jid.2021.06.016. Epub 2021 Aug 6.
Abstract
Palmoplantar skin has several unique characteristics such as increased thickness, high resilience, hypopigmentation, and lack of hair follicles. The establishment of palmoplantar identity occurs through keratinocyte‒fibroblast interactions, with keratin 9 expression and Wnt signaling playing key roles. Understanding how palmoplantar features develop may help efforts to reproduce them at both palmoplantar and nonpalmoplantar body sites.
摘要
手掌和足底皮肤具有几个独特的特征，例如厚度增加、弹性高、色素减退和缺乏毛囊。手掌和足底特征的发育过程中，角质形成细胞-成纤维细胞相互作用至关重要，其中角蛋白 9 的表达和 Wnt 信号通路起关键作用。了解手掌和足底特征的发育方式可能有助于在手掌和非手掌部位的身体部位复制这些特征。
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