Akhilraj A R, Bhat Sudhakar, Priyalatha B, Vimala K S
Department of Dravyaguna (Ayurvedic Pharmacology), Amrita School of Ayurveda, Amritapuri, Amrita Vishwa Vidyapeetham, India.
Department of Pharmacology, Sri Dharmasthala Manjunatheshwara Centre for Research in Ayurveda and Allied Science, Udupi, India.
J Ayurveda Integr Med. 2021 Jul-Sep;12(3):452-457. doi: 10.1016/j.jaim.2021.04.002. Epub 2021 Aug 6.
Paracetamol (acetaminophen) toxicity is considered to be one of the major causes of drug-induced hepatic failure. Citraka (Plumbago rosea L. and Plumbago zeylanica L.) was mentioned in Ayurveda classics as a remedy in liver disorders.
OBJECTIVE(S): The aim of the study was to experimentally evaluate the comparative effect of hepatoprotective activity of detoxified root decoction of the two species of Citraka against paracetamol-induced hepatotoxicity in male Wistar albino rats.
The hepatoprotective effect of Citraka decoction of two species was evaluated by the assessment of biochemical parameters such as SGOT, SGPT, alkaline phosphatase, total bilirubin, direct bilirubin, and serum creatinine. The study was also supported by histopathological assessment of liver sections.
The results showed the elevated concentration of biochemical markers and histopathological degenerative changes in animals treated with paracetamol indicating severe hepatic damage; whereas, the treatment with decoction of both the species of Citraka showed significant reduction in the serum markers and regenerative changes in the histopathological specimens pointing towards its effectiveness as a hepatoprotective drug.
The present study showed Citraka's effectiveness as a hepatoprotective drug and proved that the detoxified root decoction of P. rosea L. has a significant protective activity against paracetamol-induced hepatotoxicity than P. zeylanica L.
对乙酰氨基酚毒性被认为是药物性肝衰竭的主要原因之一。紫茉莉（Plumbago rosea L. 和 Plumbago zeylanica L.）在阿育吠陀经典中被提及为治疗肝脏疾病的药物。
本研究的目的是通过实验评估两种紫茉莉解毒根煎剂对雄性Wistar白化大鼠扑热息痛诱导的肝毒性的保肝活性比较效果。
通过评估生化参数如谷草转氨酶、谷丙转氨酶、碱性磷酸酶、总胆红素、直接胆红素和血清肌酐来评价两种紫茉莉煎剂的保肝作用。该研究还得到了肝脏切片组织病理学评估的支持。
结果显示，用扑热息痛治疗的动物生化标志物浓度升高，组织病理学出现退行性变化，表明肝脏严重受损；而用两种紫茉莉煎剂治疗后，血清标志物显著降低，组织病理学标本出现再生变化，表明其作为保肝药物的有效性。
本研究表明紫茉莉作为保肝药物的有效性，并证明玫瑰紫茉莉解毒根煎剂对扑热息痛诱导的肝毒性比铅叶紫茉莉具有显著的保护活性。
