神经心理学预测因素对阿尔茨海默病多民族社区队列患者严重功能依赖的影响。
Neuropsychological Predictors of Severe Functional Dependency in a Multiethnic Community Cohort of Individuals with Alzheimer's Disease.
机构信息
Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
出版信息
J Alzheimers Dis. 2021;83(2):539-544. doi: 10.3233/JAD-210019.
To assess the predictive value of neuropsychological tests for severe dependency in Alzheimer's disease as defined by the Equivalent Institutional Care Rating Scale, in a multiethnic, community cohort. The sample included 146 elders from the Predictors 3 cohort. Cox proportional hazard models tested the predictive value of each neuropsychological test at baseline on relative risk of meeting severe dependency. Higher semantic processing and memory test scores at baseline were associated with lower risk of meeting severe dependency in the adjusted Cox models. The integrity of semantic processing and memory abilities in dementia appears to predict time to severe functional dependency.
为了评估神经心理学测试在多民族、社区队列中对等效机构护理评分量表定义的阿尔茨海默病严重依赖的预测价值。该样本包括来自预测者 3 队列的 146 位老年人。Cox 比例风险模型测试了基线时每项神经心理学测试对达到严重依赖的相对风险的预测价值。调整后的 Cox 模型显示，基线时较高的语义处理和记忆测试分数与较低的严重依赖风险相关。痴呆症中语义处理和记忆能力的完整性似乎可以预测严重功能依赖的时间。
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