低蛋白饮食中氨基酸和酮酸补充剂引起的超滤过：对肌酐清除率的影响。
Hyperfiltration due to amino and keto acid supplements of low-protein diets: influence on creatinine clearance.
作者信息
Gretz N, Meisinger E, Strauch M
机构信息
Clinic of Nephrology, University of Heidelberg, Klinikum Mannheim, FRG.
出版信息
Infusionsther Klin Ernahr. 1987 Oct;14 Suppl 5:30-3. doi: 10.1159/000226325.
In 12 male 5/6 nephrectomized Sprague-Dawley rats we analyzed the influence of commercially available amino/keto acid supplements on creatinine clearance. The addition of different supplements to an 8% protein diet resulted in an increase of creatinine clearance. Keto acids per se do not seem to cause a remarkable increase in creatinine clearance/hyperfiltration. Our data underline the importance of the protein content of a low-protein diet and the composition of amino/keto acid supplements, as these factors per se can cause hyperfiltration and might accelerate progression of chronic renal failure.
在12只雄性5/6肾切除的Sprague-Dawley大鼠中，我们分析了市售氨基酸/酮酸补充剂对肌酐清除率的影响。在8%蛋白质饮食中添加不同的补充剂会导致肌酐清除率增加。酮酸本身似乎不会引起肌酐清除率显著增加/超滤。我们的数据强调了低蛋白饮食中蛋白质含量以及氨基酸/酮酸补充剂组成的重要性，因为这些因素本身可导致超滤，并可能加速慢性肾衰竭的进展。
Zotero 插件