1H核磁共振的远程耦合在2,4 - 二取代 - 5(4H)-恶唑酮以及由三乙胺作用产生的4 - 烷基 - 5(2H)-恶唑酮中的情况。
1H n.m.r. long-range coupling in 2,4-disubstituted-5(4H)-oxazolones and 4-alkyl-5(2H)-oxazolones generated therefrom by the action of triethylamine.
作者信息
Chen F M, Benoiton N L
机构信息
Department of Biochemistry, University of Ottawa, Ontario, Canada.
出版信息
Int J Pept Protein Res. 1987 Nov;30(5):683-8. doi: 10.1111/j.1399-3011.1987.tb03380.x.
Abstract
Long-range couplings were observed between H-4 and 2-CCHn of 2,4-disubstituted-5(4H)-oxazolones, and H-4 and H-2 of 4-alkyl-5(4H)-oxazolones. In the presence of triethylamine, H-4 of the latter migrates to C-2 accompanied by a shift of the double bond to give 4-alkyl-5(2H)-oxazolones which show 5J coupling between H2-2 and 4-CCHn protons.
摘要
在2,4-二取代-5(4H)-恶唑酮的H-4与2-CCHn以及4-烷基-5(4H)-恶唑酮的H-4与H-2之间观察到远程偶合。在三乙胺存在下，后者的H-4迁移至C-2，同时双键发生移动，生成4-烷基-5(2H)-恶唑酮，该恶唑酮在H2-2与4-CCHn质子之间显示出5J偶合。
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