5(4H)-噁唑酮作为水溶液中碳二亚胺和氰脲酰氯促进的肽活化的中间体。
5(4H)-oxazolones as intermediates in the carbodiimide- and cyanamide-promoted peptide activations in aqueous solution.
机构信息
Spectrométries et Dynamique Moléculaire, Physique des Interactions Ioniques et Moléculaires, UMR, CNRS-Aix-Marseille Université, France.
出版信息
Angew Chem Int Ed Engl. 2013 Jan 7;52(2):611-4. doi: 10.1002/anie.201207730. Epub 2012 Nov 21.
PMID:23169705
Abstract
The early days: although considered a species to be avoided in peptide chemistry, the intermediacy of 5(4H)-oxazolones is demonstrated to be essential for the formation of peptides through cyanamide and carbodiimide activation in aqueous solution.
摘要
早期
尽管在肽化学中被认为是一种需要避免的物质，但 5(4H)-噁唑啉酮的中间体在通过氰胺和碳二亚胺在水溶液中的活化形成肽时被证明是必不可少的。
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