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基于许可的区块链临床试验服务平台，提高试验数据透明度。

A Permissioned Blockchain-Based Clinical Trial Service Platform to Improve Trial Data Transparency.

机构信息

Shanghai Normal University Tianhua College, Shanghai 201815, China.

Daegu-Gyeongbuk Research Center, Electronics and Telecommunications Research Institute, Daegu 42994, Republic of Korea.

出版信息

Biomed Res Int. 2021 Jul 29;2021:5554487. doi: 10.1155/2021/5554487. eCollection 2021.

DOI:10.1155/2021/5554487
PMID:34368352
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8346314/
Abstract

The clinical research faces numerous challenges, from patient enrollment to data privacy concerns and regulatory requirements to spiraling costs. Blockchain technology has the potential to overcome these challenges, thus making clinical trials transparent and enhancing public trust in a fair and open process with all stakeholders because of its distinct features such as data immutability and transparency. This paper proposes a permissioned blockchain platform to ensure clinical data transparency and provides secure clinical trial-related solutions. We explore the core functionalities of blockchain applied to clinical trials and illustrate its general principle concretely. These clinical trial operations are automated using the smart contract, which ensures traceability, prevents a posteriori reconstruction, and securely automates the clinical trial. A web-based user interface is also implemented to visualize the data from the blockchain and ease the interaction with the blockchain network. A proof of concept is implemented on Hyperledger Fabric in the case study of clinical management for multiple clinical trials to demonstrate the designed approach's feasibility. Lastly, the experiment results demonstrate the efficiency and usability of the proposed platform.

摘要

临床研究面临着诸多挑战，从患者招募到数据隐私问题，再到监管要求和不断攀升的成本。区块链技术具有克服这些挑战的潜力，因为它具有数据不可变和透明度等独特功能，从而使临床试验具有透明性，并增强了公众对公平和开放过程的信任，所有利益相关者都可以从中受益。本文提出了一个许可区块链平台，以确保临床数据的透明度，并提供安全的临床试验相关解决方案。我们探索了区块链在临床试验中的核心功能，并具体说明了其一般原理。这些临床试验操作是使用智能合约自动执行的，这确保了可追溯性、防止事后重建，并安全地自动化了临床试验。还实现了一个基于 Web 的用户界面，用于可视化来自区块链的数据，并简化与区块链网络的交互。在多临床试验的临床管理案例研究中，在 Hyperledger Fabric 上实现了概念验证，以证明所设计方法的可行性。最后，实验结果表明了所提出平台的效率和可用性。

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3
FHIRChain: Applying Blockchain to Securely and Scalably Share Clinical Data.
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Clin Transl Sci. 2022 May;15(5):1257-1268. doi: 10.1111/cts.13246. Epub 2022 Feb 17.
FHIRChain：应用区块链安全且可扩展地共享临床数据。
Comput Struct Biotechnol J. 2018 Jul 29;16:267-278. doi: 10.1016/j.csbj.2018.07.004. eCollection 2018.
4
Blockchain Technology for Healthcare: Facilitating the Transition to Patient-Driven Interoperability.用于医疗保健的区块链技术：助力向患者驱动的互操作性转变。
Comput Struct Biotechnol J. 2018 Jun 30;16:224-230. doi: 10.1016/j.csbj.2018.06.003. eCollection 2018.
5
Secure and Trustable Electronic Medical Records Sharing using Blockchain.利用区块链实现安全可信的电子病历共享
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6
Blockchain protocols in clinical trials: Transparency and traceability of consent.临床试验中的区块链协议：同意的透明度与可追溯性
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7
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9
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J Biomed Inform. 2017 Jul;71:70-81. doi: 10.1016/j.jbi.2017.05.012. Epub 2017 May 22.
10
Improving data transparency in clinical trials using blockchain smart contracts.使用区块链智能合约提高临床试验中的数据透明度。
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