Godfrey D A, Carlson L, Ross C D
Department of Physiology, Oral Roberts University, Tulsa, Oklahoma 74171.
Hear Res. 1987 Dec 31;31(3):203-9. doi: 10.1016/0378-5955(87)90188-2.
The distribution of choline acetyltransferase activity in the cochlear nucleus of Sprague-Dawley albino rats was quantitatively compared to those in two strains of pigmented rats, Long Evans hooded and Brown Norway, using microdissection and radiometric assay techniques. Although activities tended to be, on the whole, higher in the albino rats, the differences were fairly minor. The relative distributions of choline acetyltransferase activity were generally similar among the 3 rat strains, not only among regions, but also within regions. Stain for acetylcholinesterase activity in the cochlear nucleus also had a similar appearance among the 3 rat strains. These chemical results are consistent with previous anatomical and physiological studies suggesting that auditory differences between albino and pigmented animals may not be as great in the cochlear nucleus as in the superior olivary complex.
利用显微解剖和放射测定技术，对斯普拉格-道利白化大鼠耳蜗核中胆碱乙酰转移酶活性的分布与两种有色大鼠品系（长 Evans 带帽大鼠和棕色挪威大鼠）中的分布进行了定量比较。虽然总体上白化大鼠的活性往往较高，但差异相当小。胆碱乙酰转移酶活性的相对分布在这三种大鼠品系中通常相似，不仅在不同区域之间，而且在区域内部也是如此。耳蜗核中乙酰胆碱酯酶活性的染色在这三种大鼠品系中也有相似的表现。这些化学结果与先前的解剖学和生理学研究一致，表明白化动物和有色动物之间的听觉差异在耳蜗核中可能不像在上橄榄复合体中那么大。
