Stefaniak Monika, Olszewska Beata
Department of Synthesis and Technology of Drugs, Medical University of Lodz, Łódź, Poland.
Arch Pharm (Weinheim). 2021 Dec;354(12):e2100224. doi: 10.1002/ardp.202100224. Epub 2021 Aug 8.
Benzoxazepines constitute a huge number of organic compounds widely described in the literature. Many of them are distinguished by their biological properties. Among them, our attention was drawn to 1,5-benzoxazepine derivatives due to their interesting pharmacological properties. As is reported in the literature, these compounds are not only good building blocks in organic synthesis but also have interesting biological and pharmacological properties. This article is the first review publication to describe the synthesis methods and unique properties of 1,5-benzoxazepines. Literature reports widely describe the biological properties of 1,5-benzoxazepine, like anticancer, antibacterial, or antifungal activities. 1,5-Benzoxazepine derivatives can also interact with G-protein-coupled receptors and could be incorporated into new potential drugs, among others, in treating neuronal disorders like Alzheimer's and Parkinson's disease.
苯并恶唑类化合物构成了文献中广泛描述的大量有机化合物。其中许多化合物因其生物学特性而备受关注。在这些化合物中，1,5-苯并恶唑衍生物因其有趣的药理特性而引起了我们的注意。正如文献报道的那样，这些化合物不仅是有机合成中的良好构建单元，而且还具有有趣的生物学和药理特性。本文是第一篇描述1,5-苯并恶唑类化合物合成方法和独特性质的综述性出版物。文献报道广泛描述了1,5-苯并恶唑的生物学特性，如抗癌、抗菌或抗真菌活性。1,5-苯并恶唑衍生物还可以与G蛋白偶联受体相互作用，并可纳入新的潜在药物中，用于治疗诸如阿尔茨海默病和帕金森病等神经疾病。
