Gross D M, Fisher J W
Arch Int Pharmacodyn Ther. 1978 Dec;236(2):192-201.
Terbutaline sulfate, a new synthetic beta2-adrenoceptor agonist, was found to produce a dose-related increase in 59Fe-incorporation into newly formed red blood cells of exhypoxic polycythemic mice. This effect was blocked by prior treatment of the polycythemic mice with the potent beta-adrenoceptor antagonist, DL-propranolol. Terbutaline was also infused (i.v.) (500 microgram/kg/min) into restrained unanesthetized rabbits for a period of 5 hr with constant monitoring of arterial blood pressure and periodic blood Po2, Pco2, and pH analyses. Terbutaline was found to significantly elevate plasma erythropoietin titers in rabbits while producing a slight but nonsignificant decrease in mean blood pressure. Terbutaline did not produce a significant effect upon blood gases or blood pH. These data suggest a possible involvement of beta2-adrenoceptor activation of erythropoietin production.
硫酸特布他林是一种新型合成β2 - 肾上腺素能受体激动剂，研究发现它能使低氧性红细胞增多症小鼠新生成的红细胞中59Fe的掺入量呈剂量依赖性增加。用强效β - 肾上腺素能拮抗剂DL - 普萘洛尔预先处理红细胞增多症小鼠可阻断这一效应。还将特布他林（静脉注射，500微克/千克/分钟）注入未麻醉的束缚兔体内5小时，同时持续监测动脉血压，并定期进行血液氧分压、二氧化碳分压和pH分析。结果发现，特布他林可显著提高兔血浆促红细胞生成素水平，同时使平均血压略有下降，但无统计学意义。特布他林对血气和血液pH无显著影响。这些数据表明，β2 - 肾上腺素能受体激活可能参与促红细胞生成素的产生。
