蛋白A对肥大细胞数量和巨噬细胞吞噬活性的影响。

Effect of protein A on mast cell numbers and macrophage phagocytic activity.

作者信息

Singh K P, Saxena A K, Prasad A K, Dwivedi P D, Zaidi S I, Ray P K

机构信息

Immunobiology Division, Industrial Toxicology Research Centre, Lucknow, India.

出版信息

Immunopharmacol Immunotoxicol. 1987;9(2-3):281-97. doi: 10.3109/08923978709035215.

DOI:10.3109/08923978709035215

PMID:3437103

Abstract

Swiss albino male mice were given Protein A (PA) treatment ip (0, 1.0, 6.0 or 12.0 micrograms per mouse) twice weekly for two weeks. Alterations in white blood cell counts, peritoneal cell number, peritoneal macrophage and mast cell number were found. Macrophage induced phagocytosis of sheep red blood cells was also found enhanced in PA group. The maximum effect was found in 1.0 microgram of PA dose group of mice. From our studies it can be derived that PA induced tumor regression may be due to potentiation of macrophage induced antitumor activity.

摘要

给瑞士白化雄性小鼠腹腔注射蛋白A（PA）（每只小鼠0、1.0、6.0或12.0微克），每周两次，持续两周。发现白细胞计数、腹腔细胞数量、腹腔巨噬细胞和肥大细胞数量有变化。还发现PA组巨噬细胞诱导的绵羊红细胞吞噬作用增强。在PA剂量为1.0微克的小鼠组中发现了最大效果。从我们的研究中可以得出，PA诱导的肿瘤消退可能是由于巨噬细胞诱导的抗肿瘤活性增强。