Zhonghua Gan Zang Bing Za Zhi. 2021 Jul 20;29(7):636-647. doi: 10.3760/cma.j.cn501113-20210604-00261.
Combined immunotherapy based on immune checkpoint inhibitors (ICIs) for hepatocellular carcinoma has achieved remarkable therapeutic effect in clinical research and practice. However, many problems that need to be resolved have also been recognized in the clinical promotion process. Therefore, the primary effort through the multidisciplinary experts' mutual discussion [Chinese multidisciplinary expert consensus on combined immunotherapy based on immune check point inhibitors for hepatocellular carcinoma (2021 version)] is to implement the principles and methods of clinical application of ICIs treatment, including the selection of indications, prescriptions, treatment methods, monitoring and management of treatment process and adverse reactions, and efficacy evaluation. In addition, the consensus aims to combine the latest research progress, summarize detailed clinical application rules and expert experience, so as to provide reference for health professionals.
基于免疫检查点抑制剂(ICIs)的联合免疫疗法在肝细胞癌的临床研究和实践中取得了显著的治疗效果。然而,在临床推广过程中也认识到了许多需要解决的问题。因此,通过多学科专家相互讨论[《中国肝细胞癌免疫检查点抑制剂联合免疫治疗多学科专家共识(2021版)》]的首要努力是落实ICIs治疗临床应用的原则和方法,包括适应证选择、处方、治疗方法、治疗过程及不良反应的监测与管理以及疗效评估。此外,该共识旨在结合最新研究进展,总结详细的临床应用规则和专家经验,以便为卫生专业人员提供参考。