Lu Qian, Lou Jun, Cai Ruyun, Han Weidong, Pan Hongming
Department of Medical Oncology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Department of Colorectal Surgery, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Cancer Cell Int. 2021 Aug 9;21(1):417. doi: 10.1186/s12935-021-02123-3.
Long non-coding RNAs refer to transcripts over 200 nt in length that lack the ability to encode proteins, which occupy the majority of the genome and play a crucial role in the occurrence and development of human diseases, especially cancers. SBF2-AS1, a newly identified long non-coding RNA, has been verified to be highly expressed in diversiform cancers, and is involved in processes promoting tumorigenesis, tumor progression and tumor metastasis. Moreover, upregulation of SBF2-AS1 expression was significantly related to disadvantageous clinicopathologic characteristics and indicated poor prognosis. In this review, we comprehensively summarize the up-to-date knowledge of the detailed mechanisms and underlying functions of SBF2-AS1 in diverse cancer types, highlighting the potential of SBF2-AS1 as a diagnostic and prognostic biomarker and even a therapeutic target.
长链非编码RNA是指长度超过200个核苷酸且缺乏编码蛋白质能力的转录本，它们占据了基因组的大部分，并在人类疾病尤其是癌症的发生和发展中发挥着关键作用。SBF2-AS1是一种新鉴定的长链非编码RNA，已被证实在多种癌症中高表达，并参与促进肿瘤发生、肿瘤进展和肿瘤转移的过程。此外，SBF2-AS1表达上调与不利的临床病理特征显著相关，提示预后不良。在这篇综述中，我们全面总结了SBF2-AS1在不同癌症类型中的详细机制和潜在功能的最新知识，强调了SBF2-AS1作为诊断和预后生物标志物甚至治疗靶点的潜力。
