γ-乙烯基γ-氨基丁酸在迟发性运动障碍中的临床和生化效应。
Clinical and biochemical effects of gamma-vinyl Gaba in tardive dyskinesia.
作者信息
Gaio J M, Pollak P, Hommel M, Perret J
机构信息
Clinique Neurologique, CHU Grenoble, France.
出版信息
J Neurol Neurosurg Psychiatry. 1987 Dec;50(12):1674-8. doi: 10.1136/jnnp.50.12.1674.
Abstract
Clinical and biochemical effects of Gamma-vinyl-Gaba (GVG) have been evaluated in a blind video-controlled study in 10 psychiatric patients (mean age 71 yr) with tardive dyskinesia. CSF free and total Gaba and homocarnosine concentrations increased from three to five fold with GVG treatment. Despite the GVG-induced biological effects on Gaba metabolism, GVG did not consistently improve tardive dyskinesia. Psychomotor side-effects occurred in older patients, who only tolerated GVG dosages of 2-4 g/day.
摘要
在一项针对10名患有迟发性运动障碍的精神病患者（平均年龄71岁）的双盲视频对照研究中，对γ-乙烯基-GABA（GVG）的临床和生化作用进行了评估。接受GVG治疗后，脑脊液中游离和总GABA以及高肌肽浓度增加了三到五倍。尽管GVG对GABA代谢产生了生物学效应，但GVG并不能持续改善迟发性运动障碍。年龄较大的患者出现了精神运动性副作用，他们仅能耐受2-4克/天的GVG剂量。
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