Department of Pharmacology and Physiology, Henry and Amelia Nasrallah Center for Neuroscience, Saint Louis University School of Medicine, St. Louis, Missouri.
Department of Pathology, Henry and Amelia Nasrallah Center for Neuroscience, Saint Louis University School of Medicine, St. Louis, Missouri.
Mo Med. 2021 Jul-Aug;118(4):352-357.
G protein-coupled receptors (GPCRs) transmit the signals of a variety of hormones and neurotransmitters and are targets of more than 30% of all FDA-approved drugs. We developed an approach for identifying the endogenous ligands for a family of orphan GPCRs that enables the development of novel therapeutics for the potential treatment of a wide variety of disorders including pain, diabetes, appetitive behaviors, infertility and obesity. With this approach, we have deorphanized five previously orphaned GPCRs.
G 蛋白偶联受体（GPCRs）传递各种激素和神经递质的信号，是美国食品和药物管理局批准的 30%以上药物的靶点。我们开发了一种鉴定一组孤儿 GPCR 内源性配体的方法，为开发新的治疗方法提供了可能，这些治疗方法可能用于治疗包括疼痛、糖尿病、食欲行为、不孕和肥胖在内的多种疾病。通过这种方法，我们已经使五个以前的孤儿 GPCR 得到了功能鉴定。
