Department of Urology, University of Miami Miller School of Medicine, Miami, Florida, USA.
Andrologia. 2021 Dec;53(11):e14210. doi: 10.1111/and.14210. Epub 2021 Aug 9.
There is an androgen effect on haematopoiesis; however, the effect of low testosterone in anaemia has not been fully studied. In this study, we aim to explore the association of total serum testosterone, low testosterone (≤300 ng/dl), haemoglobin concentration and prevalence of anaemia in a nationally representative sample of men. We analysed data from the NHANES III database, and men between the age of 18-80 years of age were selected. We defined anaemia as haemoglobin ≤13.5 ng/dl and low serum testosterone as ≤300 ng/dl. After analysing 5,888 men, it was shown that those with anaemia had a higher prevalence of low serum testosterone (32.3%) compared to those without anaemia (24.1%) (p < .001), and in multivariable-adjusted analysis, it was shown that low testosterone was significantly associated with anaemia (OR = 1.44; 95% CI: 1.17-1.78; p = .001). Our findings suggest that men with low serum testosterone have a higher risk of anaemia, and there is a positive association between serum testosterone and serum Hb. Further prospective studies need to be performed to confirm our findings.
雄激素对造血有影响；然而，低睾酮与贫血的关系尚未得到充分研究。在这项研究中，我们旨在探讨总血清睾酮、低睾酮（≤300ng/dl）、血红蛋白浓度和贫血患病率在全国代表性男性样本中的关联。我们分析了 NHANES III 数据库的数据，并选择了年龄在 18-80 岁之间的男性。我们将贫血定义为血红蛋白≤13.5ng/dl，低血清睾酮定义为≤300ng/dl。在分析了 5888 名男性后，结果表明贫血患者低血清睾酮的患病率（32.3%）明显高于非贫血患者（24.1%）（p<0.001），在多变量调整分析中，低血清睾酮与贫血显著相关（OR=1.44；95%CI：1.17-1.78；p=0.001）。我们的研究结果表明，低血清睾酮的男性贫血风险更高，血清睾酮与血清 Hb 之间存在正相关。需要进一步进行前瞻性研究来证实我们的发现。
