Mukamel M, Bernstein B H, Brik R, Lehman T J
Department of Pediatrics, University of Southern California School of Medicine, Los Angeles.
J Rheumatol. 1987 Dec;14(6):1147-9.
To determine the prevalence of coagulopathy in juvenile rheumatoid arthritis, results of repeated coagulation studies obtained on 73 patients over one year were correlated with disease activity, liver function abnormalities and drug therapy. In spite of active and severe disease in the majority of these children, coagulation abnormalities developed in only 2 cases and there was no instance of clinically apparent bleeding. Although these results suggest that the development of coagulopathy is uncommon, the physician must continue to exercise vigilance for this potentially life threatening complication, especially when caring for the child with systemic disease receiving combinations of drug therapy.
为了确定青少年类风湿性关节炎中凝血病的患病率，对73例患者在一年时间内反复进行凝血研究的结果与疾病活动度、肝功能异常及药物治疗情况进行了相关性分析。尽管这些儿童中的大多数患有活动性重症疾病，但仅2例出现了凝血异常，且无临床明显出血的情况。虽然这些结果表明凝血病的发生并不常见，但医生必须继续警惕这种可能危及生命的并发症，尤其是在照顾接受联合药物治疗的全身性疾病患儿时。
