评估二甲基亚砜（DMSO）对赛马药物检测干扰的可能性。

Evaluation of the potential for interference by dimethyl sulfoxide (DMSO) in drug detection in racing animals.

作者信息

Craig A M, Blythe L L, Appell L H, Slizeski M L

机构信息

College of Veterinary Medicine, Oregon State University, Corvallis.

出版信息

J Vet Pharmacol Ther. 1987 Dec;10(4):298-304. doi: 10.1111/j.1365-2885.1987.tb00105.x.

DOI:10.1111/j.1365-2885.1987.tb00105.x

PMID:3437494

Abstract

Dimethyl sulfoxide (DMSO) had been postulated to be a 'masking agent' when used concurrently with therapeutic or prohibited drugs in racing animals. Eight drugs (flunixin, furosemide, caffeine, apomorphine, phenylbutazone, lidocaine, cocaine, and acepromazine maleate) were administered to six horses singly and with concurrent intravenous DMSO. Urine samples were analyzed for the presence of the drugs and/or their metabolites by thin layer chromatography. Direct comparison of thin layer chromatograms of extracts of positive urine samples with and without DMSO verified that DMSO did not interfere with the detection of these drugs.

摘要

曾有假设认为，在赛马中，当二甲基亚砜（DMSO）与治疗性或违禁药物同时使用时，它是一种“掩蔽剂”。给六匹马单独注射以及同时静脉注射二甲基亚砜后，再分别注射八种药物（氟尼辛、呋塞米、咖啡因、阿扑吗啡、保泰松、利多卡因、可卡因和马来酸乙酰丙嗪）。通过薄层色谱法分析尿液样本中这些药物和/或其代谢物的存在情况。对有和没有二甲基亚砜的阳性尿液样本提取物的薄层色谱图进行直接比较，证实二甲基亚砜不会干扰这些药物的检测。