癌症靶向治疗耐药不可避免吗？
Is resistance to targeted therapy in cancer inevitable?
机构信息
The Peter MacCallum Cancer Centre, Melbourne, 3000 VIC, Australia; The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, 3052 VIC, Australia.
The Peter MacCallum Cancer Centre, Melbourne, 3000 VIC, Australia; The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, 3052 VIC, Australia; Department of Biochemistry and Pharmacology, University of Melbourne, Parkville, 3052 VIC, Australia.
出版信息
Cancer Cell. 2021 Aug 9;39(8):1047-1049. doi: 10.1016/j.ccell.2021.07.013.
Resistance to targeted therapies is a major challenge in cancer care and occurs via genetic and non-genetic mechanisms. In this issue of Cancer Cell, Marin-Bejar et al. demonstrate that melanomas recurrently select genetic or non-genetic resistance trajectories and that targeting neural crest stem cell-like cells prevents non-genetic, but not genetic, resistance.
耐药性是癌症治疗中的一个主要挑战，其发生是通过遗传和非遗传机制。在本期《癌细胞》杂志中，Marin-Bejar 等人表明，黑色素瘤会反复选择遗传或非遗传的耐药轨迹，并且靶向神经嵴干细胞样细胞可以预防非遗传耐药，但不能预防遗传耐药。
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