Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Pathology and Cytology, Karolinska University Laboratory, Karolinska University Hospital, Stockholm, Sweden.
Int J Infect Dis. 2021 Sep;110:433-435. doi: 10.1016/j.ijid.2021.08.005. Epub 2021 Aug 8.
The aim of this study was to estimate how well the excess mortality reflected the burden of coronavirus disease 2019 (COVID-19)-related deaths during the March-May 2020 COVID-19 outbreak in Stockholm, Sweden, and whether the excess mortality during the outbreak might have resulted in a compensatory reduced mortality after the outbreak.
Using previous 10-year or 5-year average mortality rates as a baseline, the excess mortality estimates before, during, and after the COVID-19 outbreak in March-May 2020 in Stockholm were compared.
Weekly death estimates revealed that the immediate pre-outbreak and post-outbreak all-cause mortality did not exceed to excess mortality regardless of whether previous 10-year or 5-year average mortality was used. Forty-three days after the start of the outbreak, 74.4% of the total excess mortality was reportedly explained by known COVID-19-related deaths, and the present study reports an update, showing that 15 weeks after the start of the outbreak, the reported COVID-19-related deaths explained >99% of the total excess mortality.
An exceptional outbreak feature of rapid excess mortality was observed. However, no excess but similarly low mortality was observed immediately prior to the outbreak and post-outbreak, thus emphasizing the severity of the first wave of the COVID-19 outbreak in Stockholm.
本研究旨在评估 2020 年 3 月至 5 月瑞典斯德哥尔摩 COVID-19 爆发期间,超额死亡率反映 2019 年冠状病毒病(COVID-19)相关死亡负担的程度,以及 COVID-19 爆发期间的超额死亡率是否可能导致爆发后死亡人数减少。
使用前 10 年或 5 年的平均死亡率作为基线,比较 2020 年 3 月至 5 月 COVID-19 爆发前、期间和之后斯德哥尔摩的超额死亡率估计。
每周的死亡估计表明,无论使用前 10 年还是 5 年的平均死亡率,爆发前和爆发后的全因死亡率均未超过超额死亡率。在疫情爆发 43 天后,据报道,已知与 COVID-19 相关的死亡已解释了总超额死亡的 74.4%,本研究报告了一个更新结果,表明在疫情爆发 15 周后,报告的 COVID-19 相关死亡解释了总超额死亡的>99%。
观察到异常爆发的快速超额死亡率特征。然而,在爆发前和爆发后,并没有出现超额死亡率,而是同样低的死亡率,因此强调了斯德哥尔摩 COVID-19 爆发第一波的严重性。