Interleukin Polymorphisms and Predisposition of Systemic Lupus Erythematosus: A Meta-Analysis.

BACKGROUND

It is plausible that interleukin polymorphisms may affect predisposition of autoimmune disorders such as systemic lupus erythematosus (SLE), but the results of so far published studies remain controversial.

OBJECTIVES

The authors conducted this meta-analysis to clarify relationships between interleukin-1 (IL-1)/interleukin-4 (IL-4)/interleukin-6 (IL-6)/interleukin-10 (IL-10) polymorphisms and SLE by pooling the findings of eligible studies.

METHODS

A comprehensive search of PubMed, EMBASE, Web of Science, and CNKI was endorsed by the authors to identify already published studies. Fifty-seven studies were found to be eligible for meta-analyses.

RESULTS

The overall pooled meta-analyses yielded positive findings for IL-1A -889 C/T, IL-1B -31 T/C, IL-6 -174 G/C, IL-4 -590 C/T, and IL-10 -1,082 A/G polymorphisms. In addition, we also detected similar positive findings for IL-1B -511 C/T, IL-4 -590 C/T, IL-10 -592 A/C, IL-10 -819 C/T, and IL-10 -1,082 A/G polymorphisms in Asians, and such positive findings were also observed for IL-1A -889 C/T, IL-6 -174 G/C, and IL-10 -1,082 A/G polymorphisms in Caucasians.

CONCLUSIONS

The meta-analyses' results suggest that IL-1A -889 C/T, IL-1B -31 T/C, IL-6 -174 G/C, IL-4 -590 C/T, and IL-10 -1,082 A/G polymorphisms might affect predisposition of SLE.