Assistant professor and undergraduate program director, Gene W. Hirschfeld School of Dental Hygiene from Old Dominion University, Norfolk, VA, USA.
Student in the Department of Biological Sciences from Old Dominion University, Norfolk, VA, USA.
J Dent Hyg. 2021 Aug;95(4):23-31.
Orofacial manifestations of Lyme disease can affect head and neck anatomical structures that are frequently examined by dental professionals. The purpose of this systematic review was to examine the literature for types and frequencies of orofacial manifestations documented in populations in the United States (US) with Lyme disease. Four electronic databases (Dentistry and Oral Sciences, PubMed, Cinahl Plus, and Medline) were systematically searched during the summer of 2019 using keywords and MeSH terms to identify relevant studies. Search term alterations and synonyms were cross-checked using the US National Library of Medicine Unified Medical Language System Metathesaurus. Full-text, English language studies were included if they reported on US populations with Centers for Disease Control and Prevention confirmed cases of Lyme disease. The review followed guidelines set forth in Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA). Quality was assessed with a modified version of the Cochrane Data Collection Form for Randomized Control Trials and Non-randomized Control Trials. Extracted data was organized by themes of manifestations and the frequencies were calculated. An initial search extracted 217,381 articles; 43 met the inclusion criteria and were further reviewed for quality. Twelve articles published from 1992-2017 were deemed appropriate for inclusion. All were from non-dental journals and fewer than half (n=6) reported on Lyme disease endemic states. Eight incidences of orofacial manifestations within head/neck regions were documented in Lyme disease patients (n=951) and included: headache (39.5%), facial palsy (42.5%), temporomandibular joint arthralgia (42.0%), altered taste (11.0%), stiff neck (13.6%), sore throat (3.0%), neck pain/arthralgia (7.5%), and erythema migrans rash (5.2%). Eight orofacial manifestations of Lyme disease were revealed by this systematic review. Future research regarding the orofacial manifestations of Lyme disease is needed so this medical condition can be better understood by oral health care providers and result in improved health outcomes for infected patients.
莱姆病的口腔颌面部表现可影响头颈部解剖结构，这些结构经常由牙科专业人员检查。本系统评价的目的是检查美国莱姆病患者人群中记录的口腔颌面部表现的类型和频率的文献。2019 年夏季，使用关键词和 MeSH 术语在四个电子数据库（牙科和口腔科学、PubMed、 Cinahl Plus 和 Medline）中进行了系统检索，以识别相关研究。使用美国国立医学图书馆统一医学语言系统术语集对检索词的变化和同义词进行了交叉检查。如果研究报告了美国疾病控制与预防中心确认的莱姆病病例，则纳入全文为英文的研究。本综述遵循系统评价和荟萃分析的首选报告项目（PRISMA）规定。使用 Cochrane 数据采集表格对随机对照试验和非随机对照试验进行了质量评估。提取的数据按表现主题进行组织，并计算了频率。初步搜索提取了 217381 篇文章；43 篇符合纳入标准，并进一步进行了质量审查。1992 年至 2017 年发表的 12 篇文章被认为适合纳入。所有文章均来自非牙科期刊，不到一半（n=6）报告了莱姆病流行州。在莱姆病患者（n=951）中记录了 8 例头颈部区域的口腔颌面部表现，包括：头痛（39.5%）、面瘫（42.5%）、颞下颌关节关节炎（42.0%）、味觉改变（11.0%）、颈项强直（13.6%）、咽痛（3.0%）、颈痛/关节炎（7.5%）和游走性红斑皮疹（5.2%）。本系统评价揭示了莱姆病的 8 种口腔颌面部表现。需要进一步研究莱姆病的口腔颌面部表现，以便口腔保健提供者更好地了解这种疾病，并为感染患者带来更好的健康结果。
