Horisawa Shiro, Taira Takaomi
Department of Neurosurgery, Tokyo Women's Medical University.
No Shinkei Geka. 2021 Jul;49(4):838-845. doi: 10.11477/mf.1436204462.
Radiofrequency lesioning surgery is primarily performed to treat Parkinson's disease, dystonia, and tremor. Its effects are similar to those of deep brain stimulation (DBS). However, Radiofrequency lesioning surgery has not been popularized, possibly due to the over-evaluation of its risks. The current most available targets for the treatment of movement disorders include ventral intermediate (Vim) nucleus, ventral oral (Vo) nucleus, and globus pallidus internus (GPi). Vim thalamotomy is available for Parkinsonian tremor, essential tremor, dystonic tremor, and other various kinds of tremor, and it is highly effective. Bilateral vim thalamotomy is feasible when properly performed on tiny lesions on the bilateral vim nucleus. Vo thalamotomy is mainly available for focal hand dystonia. The safety profile of bilateral Vo thalamotomy has not yet been established, but it is thought that it may lead to irreversible hypophonia and dysarthria. Pallidotomy is selected for treatment of dystonia and Parkinson's disease. Although unilateral pallidotomy is a safe procedure, it can cause medically refractory parkinsonism including postural reflex disturbance and gait disorder. Delayed infarction on the posterior limb of internal capsule is another major concern associated with pallidotomy and can lead to hemiparesis. Correct understanding is absolutely essential to ensure the safety of radiofrequency lesioning surgery.
射频毁损术主要用于治疗帕金森病、肌张力障碍和震颤。其效果与脑深部电刺激(DBS)相似。然而,射频毁损术尚未得到广泛应用,可能是由于对其风险评估过高。目前治疗运动障碍最常用的靶点包括腹中间核(Vim)、腹口核(Vo)和苍白球内侧部(GPi)。丘脑腹中间核毁损术可用于治疗帕金森震颤、特发性震颤、肌张力障碍性震颤和其他各种震颤,且疗效显著。对双侧腹中间核微小病灶进行适当操作时,双侧丘脑腹中间核毁损术是可行的。丘脑腹口核毁损术主要用于治疗局限性手部肌张力障碍。双侧丘脑腹口核毁损术的安全性尚未确立,但人们认为它可能导致不可逆的声音减弱和构音障碍。苍白球毁损术用于治疗肌张力障碍和帕金森病。虽然单侧苍白球毁损术是一种安全的手术,但它可导致药物难治性帕金森综合征,包括姿势反射障碍和步态障碍。内囊后肢延迟性梗死是与苍白球毁损术相关的另一个主要问题,可导致偏瘫。正确的认识对于确保射频毁损术的安全性绝对至关重要。