配偶供体与亲属供体肾移植的结局：一项比较研究。

Outcomes of Spousal versus Parental Donor Kidney Transplants: A Comparative Study.

作者信息

Bhat Raghuram, Narayanan Sajith, Aboobacker Ismail Naduvileparambil, Hafeeq Benil, Aziz Feroz, Balakrishnan Sreejesh, Yadur Anjaney, Shafeeq Shysil, Sasindran Sooraj, Pacheerikuth Abdul Gafoor, Uvais N A

机构信息

Department of Nephrology, Aster MIMS Hospital, Kozhikode, Kerala, India.

Department of Nephrology, Iqraa International Hospital and Research Centre, Kozhikode, Kerala, India.

出版信息

Indian J Nephrol. 2021 May-Jun;31(3):261-265. doi: 10.4103/ijn.IJN_43_20. Epub 2020 Nov 7.

DOI:10.4103/ijn.IJN_43_20

PMID:34376940

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8330663/

Abstract

INTRODUCTION

Parents and spouse constitute 70% of organ donors in India. Some centres use induction immunosuppression (IS) for all spousal transplants considering it as an immunologically high risk. This study was designed to compare the outcomes of transplant recipients who received parental donors (PDs) and spousal donors (SDs) without any induction IS.

METHODS

It was a retrospective study conducted at a tertiary care hospital in South India. Adults aged 18 years or above who underwent renal transplantation from a SD or PD between January 2006 and December 2016 were included in the study.

RESULTS

Our study included 154 patients with PDs and 75 patients with SDs. The mean recipient age of the PD group was 27.79 ± 6.85 years and of the SD group was 45.62 ± 7.96 years ( < 0.001). However, the follow-up period was significantly higher for the PD group ( < 0.05). There was no significant difference between acute rejection, patient loss, mean survival, graft survival (uncensored), and death censored graft survival between two groups.

CONCLUSION

The outcomes of immunologically low-risk transplant recipients who have received PD and SD are similar and induction immunosuppression can be avoided in these patients.

摘要

引言

在印度，父母和配偶构成了70%的器官捐献者。一些中心对所有配偶间移植都采用诱导免疫抑制（IS），认为其免疫风险高。本研究旨在比较接受父母供体（PD）和配偶供体（SD）且未进行任何诱导IS的移植受者的结局。

方法

这是一项在印度南部一家三级护理医院进行的回顾性研究。纳入2006年1月至2016年12月期间接受来自SD或PD的肾移植的18岁及以上成年人。

结果

我们的研究包括154例接受PD的患者和75例接受SD的患者。PD组受者的平均年龄为27.79±6.85岁，SD组为45.62±7.96岁（<0.001）。然而，PD组的随访期显著更长（<0.05）。两组之间在急性排斥反应、患者失访、平均生存期、移植物生存期（未删失）和死亡删失移植物生存期方面没有显著差异。