Lipman Zoe M, Labib Angelina, Yosipovitch Gil
Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery and Miami Itch Center, University of Miami Miller School of Medicine, Miami, FL, USA.
Clin Cosmet Investig Dermatol. 2021 Aug 3;14:959-969. doi: 10.2147/CCID.S289716. eCollection 2021.
Pruritus is the most burdensome and prevalent symptom in patients suffering from atopic dermatitis. Treating atopic itch has historically been a challenge due to multiple underlying mechanisms within its pathogenesis and an incomplete understanding of them. In recent years, our understanding of these mechanisms have increased tremendously and subsequently, new treatments have reached the market that target the pathophysiology of atopic itch from different angles. In addition, there are several promising new treatments currently in development and trials. In the current article, we discuss these currently available treatment options, their available evidence and efficacy, and highlight some of the more recent advancements in the field.
瘙痒是特应性皮炎患者最沉重且普遍的症状。由于特应性瘙痒发病机制中的多种潜在机制以及对这些机制的不完全理解，治疗特应性瘙痒在历史上一直是一项挑战。近年来，我们对这些机制的理解有了极大的提高，随后，有针对特应性瘙痒病理生理学的不同角度的新疗法进入市场。此外，目前还有几种有前景的新疗法正在研发和试验中。在本文中，我们讨论了这些目前可用的治疗选择、它们的现有证据和疗效，并强调了该领域的一些最新进展。
