CCN5和突变型p53在乳腺癌原发灶和复发灶中的临床意义
Clinical significance of CCN5 and mutant p53 in primary and recurrent lesions of breast cancer.
作者信息
Zhou Guofeng, Gui Xingxing, Qu Wei
机构信息
Department of Pathology, The Third Hospital of Nanchang Nanchang, Jiangxi Province, China.
出版信息
Am J Transl Res. 2021 Jul 15;13(7):8433-8437. eCollection 2021.
OBJECTIVE
To analyze the expression and significance of CCN5 and mutant p53 proteins in primary and recurrent lesions of breast cancer (BC) patients.
METHODS
The expression of CCN5 and mutant p53 proteins in 20 normal breast tissues, 60 primary and chest wall recurrent lesions were detected by streptavidin peroxidase conjugated (SP) method.
RESULTS
The differences in CCN5 and mutant p53 expression is significant among normal breast tissue, primary lesion, and recurrent lesions (Χ=18.380 and Χ=30.549, P < 0.05), and the expression of CCN5 protein was higher and the expression of mutant p53 protein was lower in all primary lesions than in recurrent lesions (P < 0.05). CCN5 expression was higher in the group without lymph node metastasis (LNM) than in the group with LNM in BC patients, while mutant p53 protein expression was higher in the group with LNM than in the group without LNM (Χ=9.775, Χ=7.102, P < 0.05). There was a negative relationship between CCN5 and mutant p53 protein expression in BC tissues (r=-0.013, P < 0.001).
CONCLUSION
CCN5, mutant p53 protein expression may play different regulatory roles in BC recurrence and LNM and have important implications in BC development and prognosis.
目的
分析CCN5和突变型p53蛋白在乳腺癌（BC）患者原发灶及复发灶中的表达及意义。
方法
采用链霉亲和素-过氧化物酶偶联（SP）法检测20例正常乳腺组织、60例原发灶及胸壁复发灶中CCN5和突变型p53蛋白的表达。
结果
正常乳腺组织、原发灶和复发灶中CCN5和突变型p53的表达差异有统计学意义（χ²=18.380，χ²=30.549，P<0.05），所有原发灶中CCN5蛋白表达均高于复发灶，突变型p53蛋白表达低于复发灶（P<0.05）。乳腺癌患者无淋巴结转移（LNM）组CCN5表达高于有LNM组，而有LNM组突变型p53蛋白表达高于无LNM组（χ²=9.775，χ²=7.102，P<0.05）。乳腺癌组织中CCN5与突变型p53蛋白表达呈负相关（r=-0.013，P<0.001）。
结论
CCN5、突变型p53蛋白表达可能在乳腺癌复发及LNM中发挥不同调控作用，对乳腺癌的发生发展及预后具有重要意义。
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